|Occupation||Film director, television producer|
|Relatives||Randall Zisk (brother)|
Zisk was born to a Jewish family. After graduating from the University of Southern California, Zisk directed his first television series, Brooklyn Bridge, at the age of 26. His first feature film was The English Teacher, starring Julianne Moore, Greg Kinnear, Nathan Lane, Michael Angarano and Lily Collins.
Zisk has executive produced several series including Weeds, United States of Tara and The Larry Sanders Show. Zisk has also directed over 50 series including The Big C, Nurse Jackie, Entourage, The Office, Alias, Smash, Parks and Recreation, Shameless and Nip/Tuck.
Zisk is director of the Fox series The Exorcist.
Zisk has been nominated for several Golden Globe Awards for Weeds. He has also earned multiple Emmy nominations for The Larry Sanders Show and Weeds, including a nomination for Best Director for a Comedy.
His brother Randall Zisk is also a television director.