Clinical endocannabinoid deficiency syndrome

Clinical endocannabinoid deficiency (CECD) is a medical theory that proposes that a deficiency of endocannabinoids is the underlying pathophysiology of migraines, fibromyalgia, and irritable bowel syndrome.[1]

The nature of the syndrome and existence of CECD as a clinically meaningful condition have been called into question.[2]


  1. ^ Russo, E. B. (2004). "Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?". Neuro Endocrinology Letters. 25 (1–2): 31–9. PMID 15159679.
  2. ^ Cogan (25 May 2020). "Practical Considerations of Hypotheses and Evidence in Cannabis Pharmacotherapy: Refining Expectations of Clinical Endocannabinoid Deficiency". Journal of Dietary Supplements. 17 (5): 608–624. doi:10.1080/19390211.2020.1769246. PMID 32449630.