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Charles DeWitt (1727–1787) was a delegate to the Continental Congress of United States.

Charles DeWitt may also refer to:

  • Charles G. DeWitt (1789–1839), former member of the United States House of Representatives from New York
  • Charles W. DeWitt, Jr. (born 1947), former member of the Louisiana House of Representatives
  • Charles B. DeWitt (born 1950), former director of the National Institutes of Justice