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Cerebrolysin (developmental code name FPF-1070) is a mixture of peptides purified from pig brains, including (and not limited to) brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and ciliary neurotrophic factor (CNTF).[1][2]

While cerebrolysin is used for stroke[3] and vascular dementia, there is insufficient evidence to support this use.[4] It is also sold as a nootropic.

There is some tentative evidence of a beneficial effect on cognitive function in people with vascular dementia,[5] possibly through decreased beta-amyloid deposition.[6] Cerebrolysin is approved to treat stroke in many European and Asian countries.[citation needed]

ReferencesEdit

  1. ^ Windisch M, Gschanes A, Hutter-Paier B (1998). "Neurotrophic activities and therapeutic experience with a brain derived peptide preparation". J. Neural Transm. Suppl. 53: 289–98. PMID 9700665. 
  2. ^ Menon PK, Muresanu DF, Sharma A, Mössler H, Sharma HS (2012). "Cerebrolysin, a mixture of neurotrophic factors induces marked neuroprotection in spinal cord injury following intoxication of engineered nanoparticles from metals". CNS Neurol Disord Drug Targets. 11 (1): 40–9. doi:10.2174/187152712799960781. PMID 22229324. 
  3. ^ Ziganshina, LE; Abakumova, T; Vernay, L (5 December 2016). "Cerebrolysin for acute ischaemic stroke". The Cochrane database of systematic reviews. 12: CD007026. PMID 27918088. 
  4. ^ Chen, N; Yang, M; Guo, J; Zhou, M; Zhu, C; He, L (31 January 2013). "Cerebrolysin for vascular dementia". The Cochrane database of systematic reviews (1): CD008900. PMID 23440834. 
  5. ^ Chen, N; Yang, M; Guo, J; Zhou, M; Zhu, C; He, L (31 January 2013). "Cerebrolysin for vascular dementia". The Cochrane database of systematic reviews (1): CD008900. PMID 23440834. 
  6. ^ Masliah E, Díez-Tejedor E (2012). "The pharmacology of neurotrophic treatment with Cerebrolysin: brain protection and repair to counteract pathologies of acute and chronic neurological disorders". Drugs Today. 48 Suppl A: 3–24. doi:10.1358/dot.2012.48(Suppl.A).1739716. PMID 22514792.