A centrocyte generally refers to a B cell with a cleaved nucleus,[2] as may appear in e.g. follicular lymphoma.[3]

Histopathology of centrocytes in a follicular lymphoma. They have a thick nuclear membrane and prominent nucleoli.[1]

During B cell development, centrocytes are formed following the cessation of centroblast proliferation. Centrocytes test their newly mutated antigen-binding sites (CDR loops) by re-expressing antigen on their surface.

Centrocyte can also refer to a cell with a protoplasm that contains single and double granules of varying size stainable with hematoxylin, as seen in lesions of lichen planus,[2] or a nondividing, activated B cell that expresses membrane immunoglobulin.[2]


  1. ^ Anubha Bajaj (2018). "Susceptive, Supplemented, Stockpiled - Follicular Lymphoma" (PDF). Oncology and Cancer Case Reports. 4 (3).
    - " This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."
  2. ^ a b c [1]Stedman's Medical Dictionary. 2006 Archived 2011-09-30 at the Wayback Machine
  3. ^ Table 12-8 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7. 8th edition.