Before acting, Hernandez played the cello in several bands. In 2013, she made her debut in Machete Kills. She was cast in the ABC television series Members Only, also known as The Club, before it was cancelled in 2014. In 2016, she starred in Blair Witch and had a supporting role in La La Land.
As of 2016, Hernandez has played Samantha in the TV series Graves. In 2017, she co-starred in the sequel to Prometheus, Alien: Covenant. She will appear in Under the Silver Lake, completed and scheduled for a 2018 release.
|2013||Machete Kills||Space Babe|
|2014||Sin City: A Dame to Kill For||Thelma||Uncredited|
|2016||Blair Witch||Lisa Arlington||Main Character|
|2016||La La Land||Tracy|
|2017||The Endless||Anna||Main Character|
|2018||Under the Silver Lake||Millicent Sevence||Main Character|
|2014||From Dusk till Dawn: The Series||Jessie||Guest role; 2 episodes|
|2014||Members Only||Ana||Unaired TV series|
|2016-2017||Graves||Samantha Vega||Main role; 20 episodes|
|2019||Too Old To Die Young|
|2015||"Slumlord Rising"||The Girl||Music video by Neon Indian|
- "Callie Hernandez". Into the Gloss. Retrieved June 8, 2016.
- Petski, Denise (October 5, 2015). "Callie Hernandez Joins Epix Comedy Series 'Graves'; Showtime's Lena Waithe Pilot Casts 2". Deadline Hollywood. Retrieved June 8, 2016.
- Andreeva, Nellie (February 26, 2014). "David O. Russell Exits ABC Drama Project, Which Continues As Series, Casts 1st Actor". Deadline Hollywood. Retrieved June 8, 2016.
- Nordine, Michael (May 10, 2016). "'The Woods' Trailer: Adam Wingard Takes Us Camping in New Found-Footage Horror Flick". Indiewire. Retrieved June 8, 2016.
- Hipes, Patrick (July 8, 2015). "Sonoya Mizuno, Jessica Rothe & Callie Hernandez Move Into 'La La Land'". Deadline Hollywood. Retrieved June 8, 2016.
- Hipes, Patrick (February 25, 2016). "Alien: Covenant' Crews Up: 'Empire's Jussie Smollett, Amy Seimetz, Carmen Ejogo & More Join Cast". Deadline Hollywood. Retrieved June 8, 2016.
- N'Duka, Amanda (November 4, 2016). "'Under The Silver Lake' Adds Zosia Mamet, Jimmi Simpson, Patrick Fischler & More To Round Out Cast". Deadline Hollywood. Retrieved November 4, 2016.