Open main menu

Wikipedia β

Calcium is a chemical element with symbol Ca and atomic number 20. An alkaline earth metal, calcium is a reactive pale yellow metal that forms a dark oxide-nitride layer when exposed to air. Its physical and chemical properties are most similar to its heavier homologues strontium and barium. It is the fifth most abundant element in Earth's crust and the third most abundant metal, after iron and aluminium. The most common calcium compound on Earth is calcium carbonate, found in limestone and the fossilised remnants of early sea life; gypsum, anhydrite, fluorite, and apatite are also sources of calcium.

Calcium,  20Ca
Calcium unter Argon Schutzgasatmosphäre.jpg
Calcium Spectrum.png
Spectral lines of calcium
General properties
Pronunciation /ˈkælsiəm/
KAL-see-əm
Appearance dull gray, silver; with a pale yellow tint[1]
Calcium in the periodic table
Hydrogen (diatomic nonmetal)
Helium (noble gas)
Lithium (alkali metal)
Beryllium (alkaline earth metal)
Boron (metalloid)
Carbon (polyatomic nonmetal)
Nitrogen (diatomic nonmetal)
Oxygen (diatomic nonmetal)
Fluorine (diatomic nonmetal)
Neon (noble gas)
Sodium (alkali metal)
Magnesium (alkaline earth metal)
Aluminium (post-transition metal)
Silicon (metalloid)
Phosphorus (polyatomic nonmetal)
Sulfur (polyatomic nonmetal)
Chlorine (diatomic nonmetal)
Argon (noble gas)
Potassium (alkali metal)
Calcium (alkaline earth metal)
Scandium (transition metal)
Titanium (transition metal)
Vanadium (transition metal)
Chromium (transition metal)
Manganese (transition metal)
Iron (transition metal)
Cobalt (transition metal)
Nickel (transition metal)
Copper (transition metal)
Zinc (transition metal)
Gallium (post-transition metal)
Germanium (metalloid)
Arsenic (metalloid)
Selenium (polyatomic nonmetal)
Bromine (diatomic nonmetal)
Krypton (noble gas)
Rubidium (alkali metal)
Strontium (alkaline earth metal)
Yttrium (transition metal)
Zirconium (transition metal)
Niobium (transition metal)
Molybdenum (transition metal)
Technetium (transition metal)
Ruthenium (transition metal)
Rhodium (transition metal)
Palladium (transition metal)
Silver (transition metal)
Cadmium (transition metal)
Indium (post-transition metal)
Tin (post-transition metal)
Antimony (metalloid)
Tellurium (metalloid)
Iodine (diatomic nonmetal)
Xenon (noble gas)
Caesium (alkali metal)
Barium (alkaline earth metal)
Lanthanum (lanthanide)
Cerium (lanthanide)
Praseodymium (lanthanide)
Neodymium (lanthanide)
Promethium (lanthanide)
Samarium (lanthanide)
Europium (lanthanide)
Gadolinium (lanthanide)
Terbium (lanthanide)
Dysprosium (lanthanide)
Holmium (lanthanide)
Erbium (lanthanide)
Thulium (lanthanide)
Ytterbium (lanthanide)
Lutetium (lanthanide)
Hafnium (transition metal)
Tantalum (transition metal)
Tungsten (transition metal)
Rhenium (transition metal)
Osmium (transition metal)
Iridium (transition metal)
Platinum (transition metal)
Gold (transition metal)
Mercury (transition metal)
Thallium (post-transition metal)
Lead (post-transition metal)
Bismuth (post-transition metal)
Polonium (post-transition metal)
Astatine (metalloid)
Radon (noble gas)
Francium (alkali metal)
Radium (alkaline earth metal)
Actinium (actinide)
Thorium (actinide)
Protactinium (actinide)
Uranium (actinide)
Neptunium (actinide)
Plutonium (actinide)
Americium (actinide)
Curium (actinide)
Berkelium (actinide)
Californium (actinide)
Einsteinium (actinide)
Fermium (actinide)
Mendelevium (actinide)
Nobelium (actinide)
Lawrencium (actinide)
Rutherfordium (transition metal)
Dubnium (transition metal)
Seaborgium (transition metal)
Bohrium (transition metal)
Hassium (transition metal)
Meitnerium (unknown chemical properties)
Darmstadtium (unknown chemical properties)
Roentgenium (unknown chemical properties)
Copernicium (transition metal)
Nihonium (unknown chemical properties)
Flerovium (unknown chemical properties)
Moscovium (unknown chemical properties)
Livermorium (unknown chemical properties)
Tennessine (unknown chemical properties)
Oganesson (unknown chemical properties)
Mg

Ca

Sr
potassiumcalciumscandium
Atomic number (Z) 20
Group, period group 2 (alkaline earth metals), period 4
Block s-block
Element category   alkaline earth metal
Standard atomic weight (Ar) 40.078(4)[2]
Electron configuration [Ar] 4s2
Electrons per shell
2, 8, 8, 2
Physical properties
Phase solid
Melting point 1115 K ​(842 °C, ​1548 °F)
Boiling point 1757 K ​(1484 °C, ​2703 °F)
Density near r.t. 1.55 g/cm3
when liquid, at m.p. 1.378 g/cm3
Heat of fusion 8.54 kJ/mol
Heat of vaporisation 154.7 kJ/mol
Molar heat capacity 25.929 J/(mol·K)
Vapour pressure
P (Pa) 1 10 100 1 k 10 k 100 k
at T (K) 864 956 1071 1227 1443 1755
Atomic properties
Oxidation states +2, +1[3] ​(a strongly basic oxide)
Electronegativity Pauling scale: 1.00
Ionisation energies 1st: 589.8 kJ/mol
2nd: 1145.4 kJ/mol
3rd: 4912.4 kJ/mol
(more)
Atomic radius empirical: 197 pm
Covalent radius 176±10 pm
Van der Waals radius 231 pm
Miscellanea
Crystal structure face-centred cubic (fcc)
Face-centered cubic crystal structure for calcium
Speed of sound thin rod 3810 m/s (at 20 °C)
Thermal expansion 22.3 µm/(m·K) (at 25 °C)
Thermal conductivity 201 W/(m·K)
Electrical resistivity 33.6 nΩ·m (at 20 °C)
Magnetic ordering diamagnetic
Magnetic susceptibility (χmol) +40.0·10−6 cm3/mol[4]
Young's modulus 20 GPa
Shear modulus 7.4 GPa
Bulk modulus 17 GPa
Poisson ratio 0.31
Mohs hardness 1.75
Brinell hardness 170–416 MPa
CAS Number 7440-70-2
History
Discovery and first isolation Humphry Davy (1808)
Main isotopes of calcium
Iso­tope Abun­dance Half-life Decay mode Pro­duct
40Ca 96.941% is stable with 20 neutrons
41Ca trace 1.03×105 y ε 41K
42Ca 0.647% is stable with 22 neutrons
43Ca 0.135% is stable with 23 neutrons
44Ca 2.086% is stable with 24 neutrons
45Ca syn 162.7 d β 45Sc
46Ca 0.004% is stable with 26 neutrons
47Ca syn 4.5 d β 47Sc
γ
48Ca 0.187% 6.4×1019 y ββ 48Ti
| references | in Wikidata

The name derives from Latin calx "lime", which was obtained from heating limestone. Its compounds were known to the ancients, though their chemistry was unknown until the seventeenth century. It was isolated by Humphrey Davy in 1808 via electrolysis of its oxide, who named the element. While the pure metal does not have many applications due to its high reactivity, it is often used as an alloying component in small quantities in steelmaking, and calcium–lead alloys are sometimes used in automotive batteries. Calcium compounds on the other hand are very widely used in many industries: for example, they are used in foods and pharmaceuticals for calcium supplementation, in the paper industry as bleaches, in cement, in the manufacture of soaps, and as electrical insulators.

Calcium is the fifth most abundant element in the human body and the most abundant metal. Calcium ions play a vital role in the physiology and biochemistry of organisms and the cell as electrolytes. They play an important role in signal transduction pathways, where they act as a second messenger, in neurotransmitter release from neurons, in contraction of all muscle cell types, and in fertilization. Many enzymes require calcium ions as a cofactor. Calcium ions outside cells are also important for maintaining the potential difference across excitable cell membranes, as well as proper bone formation.

Contents

Characteristics

Classification

Calcium is a very ductile silvery metal with a pale yellow tint whose properties are very similar to the heavier elements in its group, strontium, barium, and radium. A calcium atom has twenty electrons, arranged in the electron configuration [Ar]4s2. Like the other elements placed in group 2 of the periodic table, calcium has two valence electrons in the outermost s-orbital, which are very easily lost in chemical reactions to form a dipositive ion with the stable electron configuration of a noble gas, in this case argon. Hence, calcium is almost always divalent in its compounds, which are usually ionic. Hypothetical univalent salts of calcium would be stable with respect to their elements, but not to disproportionation to the divalent salts and calcium metal, because the enthalpy of formation of MX2 is much higher than those of the hypothetical MX. This occurs because of the much greater lattice energy afforded by the more highly charged Ca2+ cation compared to the hypothetical Ca+ cation.[5]

Calcium is considered to be an alkaline earth metal, along with these heavier elements and the lighter beryllium and magnesium. Nevertheless, there are significant differences in chemical and physical properties between beryllium and magnesium (which behave more like aluminium and zinc respectively and have some of the weaker metallic character of the post-transition metals) and the group members from calcium onwards, which traditionally led to "alkaline earth metal" only applying to the latter group.[6] This classification is mostly obsolete in English-language sources, but is still used in other countries such as Japan.[7]

Physical

Calcium metal melts at 842 °C and boils at 1494 °C, higher than its adjacent group 2 metals do. It crystallises in the face-centered cubic arrangement like strontium; above 450 °C, it changes to an anisotropic hexagonal close-packed arrangement like magnesium. The density of 1.55 g·cm−3 is the lowest in its group, with others decreasing towards it.[5] Calcium can be cut with a knife with effort, although it is still harder than lead. While calcium is a poorer conductor of electricity than copper or aluminium by volume, it is a better conductor than both of them by mass due to its very low density.[8] Although it is infeasible for terrestrial applications as it reacts quickly with atmospheric oxygen, its use as a conductor in space has been considered.[9]

Chemical

 
Structure of the polymeric [Ca(H2O)6]2+ center in hydrated calcium chloride, illustrating the high coordination number typical for calcium complexes.

The chemistry of calcium is that of a typical heavy alkaline earth metal. For example, calcium spontaneously reacts with water more quickly than magnesium and less quickly than strontium to produce calcium hydroxide and hydrogen gas. It also reacts with the oxygen and nitrogen in the air to form a mixture of calcium oxide and calcium nitride.[10] When finely divided, it spontaneously burns in air to produce the nitride. In bulk, calcium is less reactive: it quickly forms a hydration coating in moist air, but below 30% relative humidity it may be stored indefinitely at room temperature.[11]

Besides the simple oxide CaO, the peroxide CaO2 can be made by direct oxidation of calcium metal under a high pressure of oxygen, and there is some evidence for a yellow superoxide Ca(O2)2.[12] Calcium hydroxide, Ca(OH)2, is a strong base, though it is not as strong as the hydroxides of strontium, barium or the alkali metals.[13] All four dihalides of calcium are known.[14] Calcium carbonate (CaCO3) and calcium sulfate (CaSO4) are particularly abundant minerals.[15] Like strontium and barium, as well as the alkali metals and the divalent lanthanides europium and ytterbium, calcium metal dissolves directly in liquid ammonia to give a dark blue solution.[5]

Due to the large size of the Ca2+ ion, high coordination numbers are common, up to 24 in some intermetallic compounds such as CaZn13.[16] Calcium is readily complexed by oxygen chelates such as EDTA and polyphosphates, which are useful in analytic chemistry and removing calcium ions from hard water. In the absence of steric hindrance, smaller group 2 cations tend to form stronger complexes, but when large polydentate macrocycles are involved the trend is reversed.[15]

Although calcium is in the same group as magnesium and organomagnesium compounds are very commonly used throughout chemistry, organocalcium compounds are not similarly widespread because they are more difficult to make and more reactive, although they have recently been investigated as possible catalysts.[17][18][19][20][21] Organocalcium compounds tend to be more similar to organoytterbium compounds due to the similar ionic radii of Yb2+ (102 pm) and Ca2+ (100 pm). Most of these compounds can only be prepared at low temperatures; bulky ligands tend to favor stability. For example, calcium dicyclopentadienyl, Ca(C5H5)2, must be made by directly reacting calcium metal with mercurocene or cyclopentadiene itself; replacing the C5H5 ligand with the bulkier C5(CH3)5 ligand on the other hand increases the compound's solubility, volatility, and kinetic stability.[22]

Isotopes

Natural calcium is a mixture of five stable isotopes (40Ca, 42Ca, 43Ca, 44Ca, and 46Ca) and one isotope with a half-life so long that it can be considered stable for all practical purposes (48Ca, with a half-life of about 4.3 × 1019 years). Calcium is the first element to have six naturally occurring isotopes.[10]

46Ca and 48Ca are the first "classically stable" nuclides with a six-neutron or eight-neutron excess respectively. Although extremely neutron-rich for such a light element, 48Ca is very stable because it is a doubly magic nucleus, having 20 protons and 28 neutrons arranged in closed shells. Its beta decay to 48Sc is very hindered because of the gross mismatch of nuclear spin: 48Ca has zero nuclear spin, being even–even, while 48Sc has spin 6+, so the decay is forbidden by the conservation of angular momentum. While two excited states of 48Sc are available for decay as well, they are also forbidden due to their high spins. As a result, when 48Ca does decay, it does so by double beta decay to 48Ti instead, being the lightest nuclide known to undergo double beta decay.[23][24] The heavy isotope 46Ca can also theoretically undergo double beta decay to 46Ti as well, but this has never been observed; the lightest and most common isotope 40Ca is also doubly magic and could undergo double electron capture to 40Ar, but this has likewise never been observed. Calcium is the only element to have two primordial doubly magic isotopes. The experimental lower limits for the half-lives of 40Ca and 46Ca are 5.9 × 1021 years and 2.8 × 1015 years respectively.[23]

By far the most common isotope of calcium in nature is 40Ca, which makes up 96.941% of all natural calcium. It is produced in the silicon-burning process from fusion of alpha particles and is the heaviest stable nuclide with equal proton and neutron numbers; its occurrence is also supplemented slowly by the decay of primordial 40K. Adding another alpha particle would lead to unstable 44Ti, which quickly decays via two successive electron captures to stable 44Ca; this makes up 2.806% of all natural calcium and is the second-most common isotope. The other four natural isotopes, 42Ca, 43Ca, 46Ca, and 48Ca, are significantly rarer, each comprising less than 1% of all natural calcium. The four lighter isotopes are mainly products of the oxygen-burning and silicon-burning processes, leaving the two heavier ones to be produced via neutron-capturing processes. 46Ca is mostly produced in a "hot" s-process, as its formation requires a rather high neutron flux to allow short-lived 45Ca to capture a neutron. 48Ca is produced by electron capture in the r-process in type Ia supernovae, where high neutron excess and low enough entropy ensures its survival.[25][26]

Apart from the practically stable 48Ca, the longest lived radioisotope of calcium is 41Ca. It decays by electron capture to stable 41K with a half-life of about a hundred thousand years. Its existence in the early Solar System as an extinct radionuclide has been inferred from excesses of 41K: traces of 41Ca also still exist today, as it is a cosmogenic nuclide, continuously reformed through neutron activation of natural 40Ca.[26] Many other calcium radioisotopes are known, ranging from 34Ca to 57Ca: they are all much shorter-lived than 41Ca, the most stable among them being 45Ca (half-life 163 days) and 47Ca (half-life 4.54 days). The isotopes lighter than 42Ca usually undergo beta plus decay to isotopes of potassium, and those heavier than 44Ca usually undergo beta minus decay to isotopes of scandium, although near the nuclear drip lines proton emission and neutron emission begin to be significant decay modes as well.[23]

Like other elements, a variety of processes alter the relative abundance of calcium isotopes.[27] The best studied of these processes is the mass-dependent fractionation of calcium isotopes that accompanies the precipitation of calcium minerals such as calcite, aragonite and apatite from solution. Lighter isotopes are preferentially incorporated into these minerals, leaving the surrounding solution enriched in heavier isotopes at a magnitude of roughly 0.025% per atomic mass unit (amu) at room temperature. Mass-dependent differences in calcium isotope composition are conventionally expressed by the ratio of two isotopes (usually 44Ca/40Ca) in a sample compared to the same ratio in a standard reference material. 44Ca/40Ca varies by about 1% among common earth materials.[28]

History

 
One of the 'Ain Ghazal Statues, made from lime plaster

Calcium compounds were known for millennia, although their chemical makeup was not understood until the 17th century.[29] Lime as a building material[30] and as plaster for statues was used as far back as around 7000 BC.[31] The first dated lime kiln dates back to 2500 BC and was found in Khafajah, Mesopotamia.[32][33] At about the same time, dehydrated gypsum (CaSO4·2H2O) was being used in the Great Pyramid of Giza; this material would later be used for the plaster in the tomb of Tutankhamun. The climate of present-day Italy being warmer than that of Egypt, the ancient Romans instead used lime mortars made by heating limestone (CaCO3); the name "calcium" itself derives from the Latin word calx "lime".[29] Vitruvius noted that the lime that resulted was lighter than the original limestone, attributing this to the boiling of the water; in 1755, Joseph Black proved that this was due to the loss of carbon dioxide, which as a gas had not been recognised by the ancient Romans.[34]

In 1787, Antoine Lavoisier suspected that lime might be an oxide of a fundamental chemical element. In his table of the elements, Lavoisier listed five "salifiable earths" (i.e., ores that could be made to react with acids to produce salts (salis = salt, in Latin): chaux (calcium oxide), magnésie (magnesia, magnesium oxide), baryte (barium sulfate), alumine (alumina, aluminium oxide), and silice (silica, silicon dioxide). About these "elements", Lavoisier speculated:

We are probably only acquainted as yet with a part of the metallic substances existing in nature, as all those which have a stronger affinity to oxygen than carbon possesses, are incapable, hitherto, of being reduced to a metallic state, and consequently, being only presented to our observation under the form of oxyds, are confounded with earths. It is extremely probable that barytes, which we have just now arranged with earths, is in this situation; for in many experiments it exhibits properties nearly approaching to those of metallic bodies. It is even possible that all the substances we call earths may be only metallic oxyds, irreducible by any hitherto known process.[35]

Calcium, along with its congeners magnesium, strontium, and barium, was first isolated by Humphry Davy in 1808. Following the work of Jöns Jakob Berzelius and Magnus Martin af Pontin on electrolysis, Davy isolated calcium and magnesium by putting a mixture of the respective metal oxides with mercury(II) oxide on a platinum plate which was used as the anode, the cathode being a platinum wire partially submerged into mercury. Electrolysis then gave calcium–mercury and magnesium–mercury amalgams, and distilling off the mercury gave the metal.[29][36] However, pure calcium cannot be prepared in bulk by this method and a workable commercial process for its production was not found until over a century later.[34]

Occurrence and production

 
Travertine terraces in Pamukkale, Turkey

At 3%, calcium is the fifth most abundant element in the Earth's crust, and the third most abundant metal behind aluminium and iron.[29] It is also the fourth most abundant element in the lunar highlands.[11] Sedimentary calcium carbonate deposits pervade the Earth's surface as fossilised remains of past marine life; they occur in two forms, the rhombohedral calcite (more common) and the orthorhombic aragonite (forming in more temperate seas). Minerals of the first type include limestone, dolomite, marble, chalk, and iceland spar; aragonite beds make up the Bahamas, the Florida Keys, and the Red Sea basins. Corals, sea shells, and pearls are mostly made up of calcium carbonate. Among the other important minerals of calcium are gypsum (CaSO4·2H2O), anhydrite (CaSO4), fluorite (CaF2), and apatite ([Ca5(PO4)3F]).[29]

The major producers of calcium are China (about 10000 to 12000 tonnes per year), Russia (about 6000 to 8000 tonnes per year), and the United States (about 2000 to 4000 tonnes per year). Canada and France are also among the minor producers. In 2005, about 24000 tonnes of calcium were produced; about half of the world's extracted calcium is used by the United States, with about 80% of the output used each year.[9] In Russia and China, Davy's method of electrolysis is still used, but is instead applied to molten calcium chloride.[9] Since calcium is less reactive than strontium or barium, the oxide–nitride coating that results in air is stable and lathe machining and other standard metallurgical techniques are suitable for calcium.[37] In the United States and Canada, calcium is instead produced by reducing lime with aluminium metal at high temperatures.[9]

Geochemical cycling

Calcium provides a link between tectonics, climate, and the carbon cycle. In the simplest terms, uplift of mountains exposes calcium-bearing rocks to chemical weathering and releases Ca2+ into surface water. These ions are transported to the ocean where they react with dissolved CO2 to form limestone, which in turn settles to the sea floor where it is incorporated into new rocks. Dissolved CO2, along with carbonate and bicarbonate ions, are termed "dissolved inorganic carbon" (DIC).[38]

The actual reaction is more complicated and involves the bicarbonate ion (HCO
3
) that forms when CO2 reacts with water at seawater pH:

Ca2+
+ 2HCO
3
CaCO
3
(limestone) + CO
2
+ H
2
O

At seawater pH, most of the CO2 is immediately converted back into HCO
3
. The reaction results in a net transport of one molecule of CO2 from the ocean/atmosphere into the lithosphere.[39] The result is that each Ca2+ ion released by chemical weathering ultimately removes one CO2 molecule from the surficial system (atmosphere, ocean, soils and living organisms), storing it in carbonate rocks where it is likely to stay for hundreds of millions of years. The weathering of calcium from rocks thus scrubs CO2 from the ocean and atmosphere, exerting a strong long-term effect on climate.[38]

Uses

The largest use of calcium is in steelmaking, due to its strong chemical affinity for oxygen and sulfur. Its oxides and sulfides, once formed, give liquid lime aluminate and sulfide inclusions in steel which float out; on treatment, these inclusions disperse throughout the steel and became small and spherical, improving castability, cleanliness and general mechanical properties. Calcium is also used in maintenance-free automotive batteries, in which the use of 0.1% calcium–lead alloys instead of the usual antimony–lead alloys leads to lower water loss and lower self-discharging. Due to the risk of expansion and cracking, aluminium is sometimes also incorporated into these alloys. These lead–calcium alloys are also used in casting, replacing lead–antimony alloys.[40] Calcium is also used to strengthen aluminium alloys used for bearings, for the control of graphitic carbon in cast iron, and to remove bismuth impurities from lead.[37] Calcium metal is found in some drain cleaners, where it functions to generate heat and calcium hydroxide that saponifies the fats and liquefies the proteins (for example, those in hair) that block drains.[41] Besides metallurgy, the reactivity of calcium is exploited to remove nitrogen from high-purity argon gas and as a getter for oxygen and nitrogen. It is also used as a reducing agent in the production of chromium, zirconium, thorium, and uranium. It can also be used to store hydrogen gas, as it reacts with hydrogen to form solid calcium hydride, from which the hydrogen can easily be re-extracted.[37]

Calcium isotope fractionation during mineral formation has led to several applications of calcium isotopes. In particular, the 1997 observation by Skulan and DePaolo[42] that calcium minerals are isotopically lighter than the solutions from which the minerals precipitate is the basis of analogous applications in medicine and in paleooceanography. In animals with skeletons mineralized with calcium, the calcium isotopic composition of soft tissues reflects the relative rate of formation and dissolution of skeletal mineral. In humans, changes in the calcium isotopic composition of urine have been shown to be related to changes in bone mineral balance. When the rate of bone formation exceeds the rate of bone resorption, the 44Ca/40Ca ratio in soft tissue rises and vice versa. Because of this relationship, calcium isotopic measurements of urine or blood may be useful in the early detection of metabolic bone diseases like osteoporosis.[43] A similar system exists in seawater, where 44Ca/40Ca tends to rise when the rate of removal of Ca2+ by mineral precipitation exceeds the input of new calcium into the ocean. In 1997 Skulan and DePaolo presented the first evidence of change in seawater 44Ca/40Ca over geologic time, along with a theoretical explanation of these changes. More recent papers have confirmed this observation, demonstrating that seawater Ca2+ concentration is not constant, and that the ocean is never in a "steady state" with respect to calcium input and output. This has important climatological implications, as the marine calcium cycle is closely tied to the carbon cycle.[44][45]

Many calcium compounds are used in food, as pharmaceuticals, and in medicine, among others. For example, calcium and phosphorus are supplemented in foods through the addition of calcium lactate, calcium diphosphate, and tricalcium phosphate. The last is also used as a polishing agent in toothpaste and in antacids. Calcium lactobionate is a white powder that is used as a suspending agent for pharmaceuticals. In baking, calcium monophosphate is used as a leavening agent. Calcium sulfite is used as a bleach in papermaking and as a disinfectant, calcium silicate is used as a reinforcing agent in rubber, and calcium acetate is a component of liming rosin and is used to make metallic soaps and synthetic resins.[40]

Biological and pathological role

Age-adjusted daily calcium requirement[46]
Age Calcium (mg/day)
0–6 months 400
6–12 months 600
1–10 years 800
11–24 years 1200
>25 years 800

Calcium is an essential element needed in large quantities. The Ca2+ ion acts as an electrolyte and is vital to the health of the muscular, circulatory, and digestive systems; is indispensable to the building of bone; and supports synthesis and function of blood cells. For example, it regulates the contraction of muscles, nerve conduction, and the clotting of blood. As a result, intra- and extracellular calcium levels are tightly regulated by the body. Calcium can play this role because the Ca2+ ion forms stable coordination complexes with many organic compounds, especially proteins; it also forms compounds with a wide range of solubilities, enabling the formation of skeletons.[46]

Calcium ions may be complexed by proteins through binding the carboxyl groups of glutamic acid or aspartic acid residues; through interacting with phosphorylated serine, tyrosine, or threonine residues; or by being chelated by γ-carboxylated amino acid residues. Trypsin, a digestive enzyme, uses the first method; osteocalcin, a bone matrix protein, uses the third. Some other bone matrix proteins such as osteopontin and bone sialoprotein use both the first and the second. Direct activation of enzymes by binding calcium is common; some other enzymes are activated by noncovalent association with direct calcium-binding enzymes. Calcium also binds to the phospholipid layer of the cell membrane, anchoring proteins associated with the cell surface.[46] As an example of the wide range of solubility of calcium compounds, monocalcium phosphate is very soluble in water, 85% of extracellular calcium is as dicalcium phosphate with a solubility of 2.0 mM and the hydroxyapatite of bones in an organic matrix is tricalcium phosphate at 100 µM.[46]

About three-quarters of dietary calcium is from dairy products and grains, the rest being accounted for by vegetables, protein-rich foods, fruits, sugar, fats, and oil. Calcium supplementation is controversial, as the bioavailability of calcium is strongly dependent on the solubility of the salt involved: calcium citrate, maltate, and lactate are highly bioavailable while the oxalate is much less so. The intestine absorbs about one-third of calcium eaten as the free ion, and plasma calcium level is then regulated by the kidneys. Parathyroid hormone and vitamin D promote the formation of bone by allowing and enhancing the deposition of calcium ions there, allowing rapid bone turnover without affecting bone mass or mineral content. When plasma calcium levels fall, cell surface receptors are activated and the secretion of parathyroid hormone occurs; it then proceeds to stimulate the entry of calcium into the plasma pool by taking it from targeted kidney, gut, and bone cells, with the bone-forming action of parathyroid hormone being antagonised by calcitonin, whose secretion increases with increasing plasma calcium levels.[46]

Excess intake of calcium may cause hypercalcaemia, but because of the inefficient absorption of calcium by the intestines a more likely cause is excessive vitamin D intake or excessive secretion of parathyroid hormone. It can also occur due to the bone destruction that occurs when tumours metastasise to bone. This results in deposition of calcium salts into the heart, the blood vessels, and the kidneys. Symptoms include anorexia, nausea, vomitting, memory loss, confusion, muscle weakness, increased urination, dehydration, and metabolic bone disease. Chronic hypercalcaemia may lead to soft tissue calcification, which can lead to serious consequences: for example, calcification of the vascular wall can lead to a loss of elasticity and the disruption of laminar blood flow, and thence to plaque rupture and thrombosis. Likewise, inadequate calcium or vitamin D intake results in hypocalcaemia, often caused by inadequate secretion of parathyroid hormone or defective receptors to it in cells. Symptoms include neuromuscular excitability, potentially causing tetany and defects in cardiac conduction.[46]

As calcium is heavily involved in bone manufacture, many bone diseases can be traced to problems with the organic matrix or the hydroxyapatite in molecular structure or organisation. For example, osteoporosis is a reduction in mineral content of bone per unit volume, and can be treated by supplementation of calcium, vitamin D, and biphosphates. Calcium supplements may benefit the serum lipids in women who have passed menopause as well as older men; in post-menopausal women calcium supplementation also appears to be inversely correlated with cardiovascular disease. Inadequate amounts of calcium, vitamin D, or phosphates can lead to the softening of bones, known as osteomalacia.[46]

Safety

Because calcium reacts exothermically with water and acids, contact of calcium metal with bodily moisture results in severe corrosive irritation.[47] When swallowed, calcium metal has the same effect on the mouth, oesophagus, and stomach, and can be fatal.[41] However, long-term exposure is not known to have distinct adverse effects.[47] As calcium is an essential element, most calcium compounds are non-toxic.[48]

See also

References

  1. ^ Greenwood, Norman N.; Earnshaw, Alan (1997). Chemistry of the Elements (2nd ed.). Butterworth-Heinemann. p. 112. ISBN 0-08-037941-9. 
  2. ^ Meija, J.; et al. (2016). "Atomic weights of the elements 2013 (IUPAC Technical Report)". Pure Appl. Chem. 88 (3): 265–91. doi:10.1515/pac-2015-0305. 
  3. ^ Krieck, Sven; Görls, Helmar; Westerhausen, Matthias (2010). "Mechanistic Elucidation of the Formation of the Inverse Ca(I) Sandwich Complex [(thf)3Ca(μ-C6H3-1,3,5-Ph3)Ca(thf)3] and Stability of Aryl-Substituted Phenylcalcium Complexes". Journal of the American Chemical Society. 132 (35): 12492–12501. PMID 20718434. doi:10.1021/ja105534w. 
  4. ^ Weast, Robert (1984). CRC, Handbook of Chemistry and Physics. Boca Raton, Florida: Chemical Rubber Company Publishing. pp. E110. ISBN 0-8493-0464-4. 
  5. ^ a b c Greenwood and Earnshaw, pp. 112–3
  6. ^ Parish, R. V. (1977). The Metallic Elements. London: Longman. p. 34. ISBN 0-582-44278-8. 
  7. ^ Fukuma, Chihito (2013). 福間の無機化学の講義 三訂版 (in Japanese). 株式会社 旺文社. p. 126. ISBN 9784010340172. 
  8. ^ Ropp, Richard C. (31 December 2012). Encyclopedia of the Alkaline Earth Compounds. p. 12–5. ISBN 978-0-444-59553-9. 
  9. ^ a b c d Ullmann, p. 484
  10. ^ a b C. R. Hammond The elements (p. 4–35) in Lide, D. R., ed. (2005). CRC Handbook of Chemistry and Physics (86th ed.). Boca Raton (FL): CRC Press. ISBN 0-8493-0486-5. 
  11. ^ a b Ullmann, p. 483
  12. ^ Greenwood and Earnshaw, p. 119
  13. ^ Greenwood and Earnshaw, p. 121
  14. ^ Greenwood and Earnshaw, p. 117
  15. ^ a b Greenwood and Earnshaw, pp. 122–5
  16. ^ Greenwood and Earnshaw, p. 115
  17. ^ Harder, S.; Feil, F.; Knoll, K. (2001). "Novel Calcium Half-Sandwich Complexes for the Living and Stereoselective Polymerization of Styrene". Angew. Chem. Int. Ed. 40: 4261–4264. doi:10.1002/1521-3773(20011119)40. 
  18. ^ Crimmin, Mark R.; Casely, Ian J.; Hill, Michael S. (2005). "Calcium-Mediated Intramolecular Hydroamination Catalysis". Journal of the American Chemical Society. 127 (7): 2042–2043. doi:10.1021/ja043576n. 
  19. ^ Jenter, Jelena; Köppe, Ralf; Roesky, Peter W. (2011). "2,5-Bis{N-(2,6-diisopropylphenyl)iminomethyl}pyrrolyl Complexes of the Heavy Alkaline Earth Metals: Synthesis, Structures, and Hydroamination Catalysis". Organometallics. 30 (6): 1404–1413. doi:10.1021/om100937c. 
  20. ^ Arrowsmith, Merle; Crimmin, Mark R.; Barrett, Anthony G. M.; Hill, Michael S.; Kociok-Köhn, Gabriele; Procopiou, Panayiotis A. (2011). "Cation Charge Density and Precatalyst Selection in Group 2-Catalyzed Aminoalkene Hydroamination". Organometallics. 30 (6): 1493–1506. doi:10.1021/om101063m. 
  21. ^ Penafiel, J.; Maron, L.; Harder, S. (2014). "Early Main Group Metal Catalysis: How Important is the Metal?". Angew. Chem. Int. Ed. doi:10.1002/anie.201408814. 
  22. ^ Greenwood and Earnshaw, pp. 136–7
  23. ^ a b c G. Audi; A. H. Wapstra; C. Thibault; J. Blachot; O. Bersillon (2003). "The NUBASE evaluation of nuclear and decay properties" (PDF). Nuclear Physics A. 729: 3–128. Bibcode:2003NuPhA.729....3A. doi:10.1016/j.nuclphysa.2003.11.001. Archived from the original (PDF) on 2008-09-23. 
  24. ^ Arnold, R.; et al. (NEMO-3 Collaboration) (2016). "Measurement of the double-beta decay half-life and search for the neutrinoless double-beta decay of 48Ca with the NEMO-3 detector". Physical Review D. 93: 112008. doi:10.1103/PhysRevD.93.112008. 
  25. ^ Cameron, A. G. W. (1973). "Abundance of the Elements in the Solar System" (PDF). Space Science Review. 15: 121–146. Bibcode:1973SSRv...15..121C. doi:10.1007/BF00172440. 
  26. ^ a b Clayton, Donald (2003). Handbook of Isotopes in the Cosmos: Hydrogen to Gallium. Cambridge University Press. p. 184–198. ISBN 9780521530835. 
  27. ^ Russell, W. A.; Papanastassiou, D. A.; Tombrello, T. A. (1978). "Ca isotope fractionation on the earth and other solar system materials". Geochim Cosmochim Acta. 42 (8): 1075–90. Bibcode:1978GeCoA..42.1075R. doi:10.1016/0016-7037(78)90105-9. 
  28. ^ Skulan, J.; Depaolo, D. J. (1999). "Calcium isotope fractionation between soft and mineralized tissues as a monitor of calcium use in vertebrates" (PDF). Proc Natl Acad Sci USA. 96 (24): 13709–13. Bibcode:1999PNAS...9613709S. PMC 24129 . PMID 10570137. doi:10.1073/pnas.96.24.13709. 
  29. ^ a b c d e Greenwood and Earnshaw, p. 108
  30. ^ Miller, M. Michael. "Commodity report:Lime" (PDF). United States Geological Survey. Retrieved 2012-03-06. 
  31. ^ Garfinkel, Yosef (1987). "Burnt Lime Products and Social Implications in the Pre-Pottery Neolithic B Villages of the Near East". Paléorient. 13 (1): 69–76. JSTOR 41492234. doi:10.3406/paleo.1987.4417. 
  32. ^ Williams, Richard (2004). Lime Kilns and Lime Burning. p. 4. ISBN 978-0-7478-0596-0. 
  33. ^ Oates, J. A. H (2008-07-01). Lime and Limestone: Chemistry and Technology, Production and Uses. ISBN 978-3-527-61201-7. 
  34. ^ a b Weeks, Mary Elvira; Leichester, Henry M. (1968). Discovery of the Elements. Easton, PA: Journal of Chemical Education. pp. 505–10. ISBN 0-7661-3872-0. LCCN 68-15217. 
  35. ^ page 218 of: Lavoisier with Robert Kerr, trans., Elements of Chemistry, … , 4th ed. (Edinburgh, Scotland: William Creech, 1799). (The original passage appears in: Lavoisier, Traité Élémentaire de Chimie, (Paris, France: Cuchet, 1789), vol. 1, p. 174.)
  36. ^ Davy, H. (1808). "Electro-chemical researches on the decomposition of the earths; with observations on the metals obtained from the alkaline earths, and on the amalgam procured from ammonia". Philosophical Transactions of the Royal Society of London. 98: 333–70. doi:10.1098/rstl.1808.0023. 
  37. ^ a b c Greenwood and Earnshaw, p. 110
  38. ^ a b Berner, Robert (2003). "The long-term carbon cycle, fossil fuels and atmospheric composition". Nature. 426 (6964): 323–326. Bibcode:2003Natur.426..323B. PMID 14628061. doi:10.1038/nature02131. 
  39. ^ Zeebe (2006). "Marine carbonate chemistry". National Council for Science and the Environment. Retrieved 2010-03-13. 
  40. ^ a b Ullmann, pp. 485–7
  41. ^ a b Rumack BH. POISINDEX. Information System Micromedex, Inc., Englewood, CO, 2010; CCIS Volume 143. Hall AH and Rumack BH (Eds)
  42. ^ Skulan, J.; Depaolo, D. J.; Owens, T. L. (June 1997). "Biological control of calcium isotopic abundances in the global calcium cycle". Geochimica et Cosmochimica Acta. 61 (12): 2505–10. Bibcode:1997GeCoA..61.2505S. doi:10.1016/S0016-7037(97)00047-1. 
  43. ^ Skulan, J.; Bullen, T.; Anbar, A. D.; Puzas, J. E.; Shackelford, L.; Leblanc, A.; Smith, S. M. (2007). "Natural calcium isotopic composition of urine as a marker of bone mineral balance" (PDF). Clinical Chemistry. 53 (6): 1155–1158. PMID 17463176. doi:10.1373/clinchem.2006.080143. 
  44. ^ Fantle, M.; Depaolo, D. (2007). "Ca isotopes in carbonate sediment and pore fluid from ODP Site 807A: The Ca2+(aq)–calcite equilibrium fractionation factor and calcite recrystallization rates in Pleistocene sediments". Geochim Cosmochim Acta. 71 (10): 2524–2546. Bibcode:2007GeCoA..71.2524F. doi:10.1016/j.gca.2007.03.006. 
  45. ^ Griffith, Elizabeth M.; Paytan, Adina; Caldeira, Ken; Bullen, Thomas; Thomas, Ellen (2008). "A Dynamic marine calcium cycle during the past 28 million years". Science. 322 (12): 1671–1674. Bibcode:2008Sci...322.1671G. PMID 19074345. doi:10.1126/science.1163614. 
  46. ^ a b c d e f g Ullmann, pp. 489–94
  47. ^ a b Ullmann, pp. 487–9
  48. ^ Tolerable Upper Intake Levels For Vitamins And Minerals (PDF), European Food Safety Authority, 2006 

Bibliography

External links