Calcium-induced calcium release
This article needs additional citations for verification. (July 2011) (Learn how and when to remove this template message)
Calcium-induced calcium release (CICR) describes a biological process whereby calcium is able to activate calcium release from intracellular Ca2+ stores (e.g., endoplasmic reticulum or sarcoplasmic reticulum). Although CICR was first proposed for skeletal muscle in the 1970s, it is now known that CICR is unlikely to be its primary mechanism for activating SR calcium release. Instead, CICR is thought to be crucial for excitation-contraction coupling in cardiac muscle and it is now obvious that CICR is a widely occurring cellular signaling process present even in many non-muscle cells, e.g. in the insulin-secreting pancreatic beta cells and many other cells. Since CICR is a positive-feedback system, it has been of great interest to elucidate the mechanism(s) responsible for its termination.
Examples in biologyEdit
Excitation-contraction coupling in myocardium relies on sarcolemma depolarization and subsequent Ca2+ entry to trigger Ca2+ release from the sarcoplasmic reticulum. When an action potential depolarizes the cell membrane, voltage-gated Ca2+ channels (e.g., L-type calcium channels) are activated. CICR occurs when the resulting Ca2+ influx activates ryanodine receptors on the SR membrane, which causes more Ca2+ to be released into the cytosol. In cardiac muscle, the result of CICR is observed as a spatio-temporally restricted Ca2+ spark. The result of CICR across the cell causes the significant increase in cytosolic Ca2+ that is important in activating muscle contraction.
- Endo, M (1977). "Calcium release from the sarcoplasmic reticulum". Physiological Reviews. 57 (1): 71–108. PMID 13441.
- Fabiato, A. (1983). "Calcium-induced calcium release from the cardiac sarcoplasmic reticulum". American Journal of Physiology. 245 (1): C1–14. PMID 6346892.
- Islam, Md.Shahidul; Rorsman, Patrik; Berggren, Per-Olof (1992). "Ca2+-induced Ca2+ release in insulin-secreting cells". FEBS Letters. 296 (3): 287–91. doi:10.1016/0014-5793(92)80306-2. PMID 1537406.