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CYP3A7 is an enzyme belonging to the cytochrome P450 family. It is 503 amino acids in size and shares 87% of its sequence with CYP3A4. It carries out a similar role in fetuses that CYP3A4 serves in adults.[5] The gene location is 7q22.1.[6]

CYP3A7
Identifiers
AliasesCYP3A7, CP37, CYPIIIA7, P-450(HFL33), P-450111A7, P450-HFLA, cytochrome P450 family 3 subfamily A member 7
External IDsMGI: 88610 HomoloGene: 133564 GeneCards: CYP3A7
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for CYP3A7
Genomic location for CYP3A7
Band7q22.1Start99,684,957 bp[1]
End99,735,196 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000765

NM_007819

RefSeq (protein)

NP_000756

NP_031845

Location (UCSC)Chr 7: 99.68 – 99.74 MbChr 5: 137.89 – 137.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The CYP3A group of enzymes are the most abundantly expressed members of the cytochrome P450 family in liver. They are responsible for the metabolism of more than 50% of all clinical pharmaceuticals.[7]

Notable allelesEdit

The CYP3A7*1C allele is associated with poor outcomes in some cancer patients, possibly because of the effect of the enzyme on some chemotherapy agents.[8]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160870 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029727 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Komori M, Nishio K, Ohi H, Kitada M, Kamataki T (February 1989). "Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450". J. Biochem. 105 (2): 161–3. PMID 2722762.
  6. ^ "Cytochrome P450, Subfamily IIIA, Polypeptide 7". OMIM. Retrieved March 14, 2013.
  7. ^ Paulussen A, Lavrijsen K, Bohets H, Hendrickx J, Verhasselt P, Luyten W, Konings F, Armstrong M (July 2000). "Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans". Pharmacogenetics. 10 (5): 415–24. doi:10.1097/00008571-200007000-00005. PMID 10898111.
  8. ^ CYP3A7*1C Allele Associated With Poor Outcomes in CLL, Breast, and Lung Cancer

External linksEdit