CSRP2BP

CSRP2 binding protein is a protein that in humans is encoded by the CSRP2BP gene.

KAT14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CU8
Identifiers
Aliases	KAT14, ATAC2, CRP2BP, PRO1194, dJ717M23.1, CSRP2BP, lysine acetyltransferase 14
External IDs	OMIM: 617501 MGI: 1917264 HomoloGene: 10745 GeneCards: KAT14
Gene location (Human) Chr. Chromosome 20 (human) Band 20p11.23 Start 18,138,118 bp End 18,188,387 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 G1|2 71.01 cM Start 144,210,903 bp End 144,249,596 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in deltoid muscle quadriceps femoris muscle vastus lateralis muscle tibialis anterior muscle gastrocnemius muscle external globus pallidus prefrontal cortex jejunum islet of Langerhans superior frontal gyrus Top expressed in internal carotid artery external carotid artery secondary oocyte hand otolith organ utricle Paneth cell primitive streak medullary collecting duct conjunctival fornix More reference expression data BioGPS n/a
Gene ontology Molecular function LIM domain binding protein binding histone acetyltransferase activity Cellular component cytoplasm nucleus Biological process G2/M transition of mitotic cell cycle histone acetylation histone H3 acetylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57325 228714 Ensembl ENSG00000149474 ENSMUSG00000027425 UniProt Q9H8E8 Q8CID0 RefSeq (mRNA) NM_020536 NM_177926 NM_001166640 NM_181417 RefSeq (protein) NP_065397 NP_001371121 NP_001160112 NP_852082 Location (UCSC) Chr 20: 18.14 – 18.19 Mb Chr 2: 144.21 – 144.25 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

CSRP2 is a protein containing two LIM domains, which are double zinc finger motifs found in proteins of diverse function. CSRP2 and some related proteins are thought to act as protein adapters, bridging two or more proteins to form a larger protein complex. The protein encoded by this gene binds to one of the LIM domains of CSRP2 and contains an acetyltransferase domain. Although the encoded protein has been detected in the cytoplasm, it is predominantly a nuclear protein. Alternatively spliced transcript variants have been described.

External links

• Human CSRP2BP genome location and CSRP2BP gene details page in the UCSC Genome Browser.

Further reading

Weiskirchen R, Gressner AM (August 2000). "The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP)". Biochemical and Biophysical Research Communications. 274 (3): 655–663. doi:10.1006/bbrc.2000.3187. PMID 10924333. Wang YL, Faiola F, Xu M, Pan S, Martinez E (December 2008). "Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein". The Journal of Biological Chemistry. 283 (49): 33808–33815. doi:10.1074/jbc.M806936200. PMC 2590711. PMID 18838386. Guelman S, Kozuka K, Mao Y, Pham V, Solloway MJ, Wang J, et al. (March 2009). "The double-histone-acetyltransferase complex ATAC is essential for mammalian development". Molecular and Cellular Biology. 29 (5): 1176–1188. doi:10.1128/MCB.01599-08. PMC 2643826. PMID 19103755. Wang K, Zhang H, Bloss CS, Duvvuri V, Kaye W, Schork NJ, et al. (September 2011). "A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa". Molecular Psychiatry. 16 (9): 949–959. doi:10.1038/mp.2010.107. PMID 21079607. S2CID 15188506.