Collagen, type V, alpha 2

  (Redirected from COL5A2)

Collagen alpha-2(V) chain is a protein that in humans is encoded by the COL5A2 gene.[5][6]

Available structures
PDBOrtholog search: PDBe RCSB
AliasesCOL5A2, EDSC, collagen type V alpha 2, collagen type V alpha 2 chain, EDSCL2
External IDsOMIM: 120190 MGI: 88458 HomoloGene: 20119 GeneCards: COL5A2
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for COL5A2
Genomic location for COL5A2
Band2q32.2Start189,031,898 bp[1]
End189,225,312 bp[1]
RNA expression pattern
PBB GE COL5A2 221730 at fs.png

PBB GE COL5A2 221729 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 2: 189.03 – 189.23 MbChr 1: 45.37 – 45.5 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome classical type, formerly known as types I and II.[6]

See alsoEdit


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000204262 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026042 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Greenspan DS, Byers MG, Eddy RL, Cheng W, Jani-Sait S, Shows TB (May 1992). "Human collagen gene COL5A1 maps to the q34.2----q34.3 region of chromosome 9, near the locus for nail-patella syndrome". Genomics. 12 (4): 836–7. doi:10.1016/0888-7543(92)90320-R. PMID 1572660.
  6. ^ a b "Entrez Gene: COL5A2 collagen, type V, alpha 2".

Further readingEdit

External linksEdit