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Creatine kinase, muscle also known as CKM is a creatine kinase that in humans is encoded by the CKM gene.[5]

Available structures
PDB Ortholog search: PDBe RCSB
Aliases CKM, CKMM, M-CK, creatine kinase, M-type, CPK-M
External IDs MGI: 88413 HomoloGene: 20432 GeneCards: CKM
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for CKM
Genomic location for CKM
Band 19q13.32 Start 45,306,414 bp[1]
End 45,322,977 bp[1]
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 19: 45.31 – 45.32 Mb Chr 7: 19.4 – 19.42 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse



In the figure to the right, the crystal structure of the muscle-type M-CK monomer is shown. In vivo, two such monomers arrange symmetrically to form the active MM-CK enzyme.


The protein encoded by this gene is a cytoplasmic enzyme involved in cellular energy homeostasis. The encoded protein reversibly catalyzes the transfer of "energy-rich" phosphate between ATP and creatine and between phospho-creatine and ADP. Its functional entity is a MM-CK homodimer in striated (sarcomeric) skeletal and cardiac muscle.

Clinical significanceEdit

In heart, in addition to the MM-CK homodimer, also the heterodimer MB-CK consisting of one muscle (M-CK) and one brain-type (B-CK) subunit is expressed. The latter may be an important serum marker for myocardial infarction, if released from damaged myocardial cells into the blood where it can be detected by clinical chemistry.


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104879 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030399 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Rosenberg UB, Kunz G, Frischauf A, Lehrach H, Mähr R, Eppenberger HM, Perriard JC (November 1982). "Molecular cloning and expression during myogenesis of sequences coding for M-creatine kinase". Proc. Natl. Acad. Sci. U.S.A. 79 (21): 6589–92. doi:10.1073/pnas.79.21.6589. PMC 347173 . PMID 6959139. 

Further readingEdit

External linksEdit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.