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CKM (gene)

Creatine kinase, muscle also known as CKM is a creatine kinase that in humans is encoded by the CKM gene.[3]

CKM
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CKM, CKMM, M-CK, creatine kinase, M-type
External IDs MGI: 88413 HomoloGene: 20432 GeneCards: CKM
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001824

NM_007710

RefSeq (protein)

NP_001815

NP_031736

Location (UCSC) Chr 19: 45.31 – 45.32 Mb Chr 7: 19.4 – 19.42 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Contents

StructureEdit

In the figure to the right, the crystal structure of the muscle-type M-CK monomer is shown. In vivo, two such monomers arrange symmetrically to form the active MM-CK enzyme.

FunctionEdit

The protein encoded by this gene is a cytoplasmic enzyme involved in cellular energy homeostasis. The encoded protein reversibly catalyzes the transfer of "energy-rich" phosphate between ATP and creatine and between phospho-creatine and ADP. Its functional entity is a MM-CK homodimer in striated (sarcomeric) skeletal and cardiac muscle.

Clinical significanceEdit

In heart, in addition to the MM-CK homodimer, also the heterodimer MB-CK consisting of one muscle (M-CK) and one brain-type (B-CK) subunit is expressed. The latter may be an important serum marker for myocardial infarction, if released from damaged myocardial cells into the blood where it can be detected by clinical chemistry.

ReferencesEdit

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Rosenberg UB, Kunz G, Frischauf A, Lehrach H, Mähr R, Eppenberger HM, Perriard JC (November 1982). "Molecular cloning and expression during myogenesis of sequences coding for M-creatine kinase". Proc. Natl. Acad. Sci. U.S.A. 79 (21): 6589–92. PMC 347173 . PMID 6959139. doi:10.1073/pnas.79.21.6589. 

Further readingEdit

External linksEdit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.