CD Lugo played its first official match against Pontevedra CF on Sunday, September 13, 1953. Lugo won it 3:1. In the 1961-62 Lugo led by the coach Luis Diestro won its first trophy, becoming Tercera División champion.
Lugo promoted for the first time to Segunda División in 1992, but could not remain more than one season in the league.
20 years later, the club promoted again to the second division after beating Cádiz in the last round of the promotion play-offs, after a penalty shootout.
In 2013 the club started its second consecutive season in the Segunda. Lugo finished in 12th position with 54 points, just 4 points from being relegated to Segunda División B.
The 2014-15 season was the sixth and the last for the coach Quique Setién. With 49 points Lugo reached 15th position and achieved the goal to retain its place in Segunda División.
In October 2017, after twelve rounds of the 2017–18 season, Lugo achieved for the first time in their history the first position of the Segunda División.
During the 2018-19 season Lugo was fighting for permanence in the Segunda División, and finally ended up on the 18th position which helped to remain for the seventh consecutive season in the second Spanish division.