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Calpain-5 is a protein that in humans is encoded by the CAPN5 gene.[5][6][7]

CAPN5
Identifiers
AliasesCAPN5, ADNIV, HTRA3, VRNI, nCL-3, calpain 5
External IDsMGI: 1100859 HomoloGene: 31212 GeneCards: CAPN5
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for CAPN5
Genomic location for CAPN5
Band11q13.5Start77,066,941 bp[1]
End77,126,155 bp[1]
RNA expression pattern
PBB GE CAPN5 205166 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004055

NM_001301250
NM_007602

RefSeq (protein)

NP_004046

NP_001288179
NP_031628

Location (UCSC)Chr 11: 77.07 – 77.13 MbChr 7: 98.12 – 98.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.[7]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149260 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035547 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Matena K, Boehm T, Dear N (Apr 1998). "Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily". Genomics. 48 (1): 117–20. doi:10.1006/geno.1997.5133. PMID 9503024.
  6. ^ Mugita N, Kimura Y, Ogawa M, Saya H, Nakao M (Dec 1997). "Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene". Biochem Biophys Res Commun. 239 (3): 845–50. doi:10.1006/bbrc.1997.7571. PMID 9367857.
  7. ^ a b "Entrez Gene: CAPN5 calpain 5".

Further readingEdit

External linksEdit