Gene C11orf16, chromosome 11 open reading frame 16, is a protein in humans that is encoded by the C11orf16 gene.[5][6] It has 7 exons, and the size of 467 amino acids.
| C11orf16 | |||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | C11orf16, chromosome 11 open reading frame 16 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 1928824 HomoloGene: 49631 GeneCards: C11orf16 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Gene edit
Location edit
The gene C11orf16 is located on chromosome 11(p15.4), starting at 8,920,076bp and ending at 8,933,006bp.
Gene neighborhood edit
Gene ASCL3 and AKIP1 are the neighbor genes of C11orf16 on chromosome 11.
Expression edit
Human edit
The gene does not have high expression throughout the body tissues. The percentile rank within the sample are higher in pancreas, ovary, and appendix.
Mouse brain edit
Even though the gene does not have a significant high expression in the mouse brain, it is most expressed in midbrain, isocortex, olfactory areas, and medulla.
Transcription factors edit
Some transcription factors that have the higher matrix similarity are Kruppel-like zinc finger protein 219, zinc finger protein 263, ZKSCAN12 (zinc finger protein with KRAB and SCAN domains 12), chorion-specific transcription factor GCMa, and Ras-responsive element binding protein 1.[7]
mRNA edit
Isoform edit
The predicted C11orf16 transcript variant X1 is 2386bp long and has NCBI accession number of XM_017018013.1.[8]
Homology edit
Paralogs edit
No paralogs were found for the C11orf16 gene through NCBI BLAST.
Orthologs edit
| Description | Common name | NCBI accession ID | Query cover | E value | Identity | Date of divergence (MYA) |
|---|---|---|---|---|---|---|
| Homo sapiens | Human | NP_065694.2 | 100 % | 0 | 100% | N/A |
| Pongo abelii | Sumatran orangutan | PNJ24628 | 84% | 0 | 95% | 15.2 |
| Aotus nancymaae | Nancy Ma's night monkey | XP_012312127.1 | 88% | 0 | 84% | 42.6 |
| Chinchilla lanigera | Long-tailed chinchilla | XP_013367496.1 | 97% | 0 | 68% | 88 |
| Equus przewalskii | Przewalski's horse | XP_008512245.1 | 98% | 0 | 73% | 94 |
| Cervus elaphus hippelaphus | Central European red deer | OWK17675.1 | 99% | 0 | 67% | 94 |
| Hipposideros armiger | Great roundleaf bat | XP_019511755.1 | 99% | 0 | 65% | 94 |
| Neomonachus schauinslandi | Hawaiian monk seal | XP_021541375.1 | 99% | 0 | 66% | 94 |
| Lipotes vexillifer | Baiji | XP_007459933.1 | 98% | 0 | 68% | 94 |
| Myotis brandtii | Brandt's bat | XP_005874017.1 | 98% | 1e-174 | 67% | 94 |
| Chelonia mydas | Green sea turtle | XP_007057171.1 | 83% | 1e-57 | 37% | 320 |
| Balearica regulorum gibbericeps | Grey crowned crane | XP_010311948.1 | 70% | 6e-5 | 40% | 320 |
Conservation edit
The gene C11orf16 is conserved in many animal species including mammals, avians, and reptiles.
Protein edit
Molecular weight edit
The predicted molecular weight of the protein encoded by C11orf16 is 51 kilodaltons.[9][10]
Domains and motifs edit
Several protein domains and motifs were found including CHD5-like protein, tyrosine kinase phosphorylation site, protein kinase C phosphorylation site, N-myristoylation site, casein kinase II phosphorylation site, and cGMP-dependent protein kinase phosphorylation site.[11] The picture indicates the location of the motifs.
Secondary structure edit
The protein is predicted to be made up with 21.2% of alpha helix, 15.2% of extended strand, and 63% of random coil.
Post-translational modifications edit
No transmembrane helices,[12] potential GPI-modification sites, or TM-proteins were found. There were seven predicted sumoylation sites,[13] multiple phosporylation sites with most of them being unspecified,[citation needed] and nine glycosylation sites.[14]
Subcellular localization predictor edit
The protein is predicted to be localized to the nucleus with the probability of 47.8%; mitochondria with the probability of 26.1%.[16]
Protein interaction edit
Proteins C1orf105 (Chromosome 1 open reading frame 105), PWWP2A, and SMYD1(SET and MYND domain containing 1) were found to be interacting with C11orf16.[17]
Clinical significance edit
Disease association edit
Protein coded by C11orf16 gene is also predicted to have 19.61% sequence identity to tumor suppressor p53-binding protein suggesting that this gene might be involved with tumor suppressing process.[18]
References edit
- ^ a b c GRCh38: Ensembl release 89: ENSG00000176029 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031022 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Amid C, Bahr A, Mujica A, Sampson N, Bikar SE, Winterpacht A, Zabel B, Hankeln T, Schmidt ER (Aug 2001). "Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7". Cytogenet Cell Genet. 93 (3–4): 284–90. doi:10.1159/000056999. PMID 11528127. S2CID 27611036.
- ^ "Entrez Gene: C11orf16 chromosome 11 open reading frame 16".
- ^ "Genomatix". Archived from the original on 2021-08-17. Retrieved 2018-05-06.
- ^ "NCBI Nucleotide". 22 November 2021.
- ^ "Expasy".
- ^ "Sigma Antibodies".
- ^ "Motif Scan".
- ^ "TMHMM".
- ^ "SUMOplot".
- ^ "YingOYang".
- ^ "Protter".
- ^ "PSORTII".[permanent dead link]
- ^ "String".
- ^ "SWISS-MODEL". Archived from the original on 2018-05-07. Retrieved 2018-05-06.
External links edit
- Human C11orf16 genome location and C11orf16 gene details page in the UCSC Genome Browser.
- C11orf16 information on GeneCards
Further reading edit
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.