Bugisu sub-region is a region in Eastern Uganda that consists of the following districts:

The sub-region is home mainly to the Gisu people, also called Bagisu, (singular is Mugisu). The Bagisu speak Lugisu, a dialect of Lumasaba, a Bantu language. Lugisu is very similar to the Bukusu language spoken of the Bukusu people of Kenya.

According to the 2002 national census, the Bugisu sub-region was home to an estimated 1 million people at that time.[1]

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01°12′N 34°24′E / 1.200°N 34.400°E / 1.200; 34.400