Brook Street is one of the principal streets on the Grosvenor Estate in the exclusive central London district of Mayfair. Named after the Tyburn Brook that formerly ran nearby, it was developed in the first half of the 18th century and runs from Hanover Square to Grosvenor Square. The continuation from Grosvenor Square to Park Lane is called Upper Brook Street. Both sections originally consisted of typical London terraced houses, mostly built to individual designs. Some of them are quite grand and were designed by well known architects for aristocratic clients, especially near Grosvenor Square, while others are more modest. Some of the original houses survive while others have been replaced by buildings from a variety of periods.
Features of the street include the grand hotel Claridge's, at the junction with Davies Street, and Le Gavroche, a famous restaurant. The former United States Embassy, which abutted Upper Brook Street and Grosvenor Square, necessitated security arrangements which impeded free access to the former. The Embassy of Argentina is at number 65. The Handel & Hendrix in London is also in Brook Street, occupying numbers 23 and 25, the former residences of famous musicians Jimi Hendrix and Handel.
- 23 Brook Street: Jimi Hendrix, guitarist.
- 25 Brook Street: George Frideric Handel, composer.
- 39 Brook Street: Sir Jeffry Wyatville, architect.
- 39 Brook Street: Sibyl, Lady Colefax and John Fowler, interior decorator and interior designer.
- 54 Brook Street: Valentine Ackland, poet, was born here.
- 67 Brook Street: Barry, Robin, and Maurice Gibb, musicians, better known as the Bee Gees.
- 74 Brook Street: Sir William Gull, Royal physician.
- 74 Brook Street: Robert Bentley Todd, physician.
- 76 Brook Street: Colen Campbell, architect.
- 78 Brook Street: Ronald Firbank, novelist.
- 22 Upper Brook Street: Leo Bonn, founder of what became the Royal National Institute for Deaf People.
- 24 Upper Brook Street: Richard Bull, MP and art collector.
- 27 Upper Brook Street: Anne Seymour Damer, sculptor
- 35 Upper Brook Street: William Jowitt, 1st Earl Jowitt, lawyer and politician (the interior received mosaics by Boris Anrep in 1923).
- 40 Upper Brook Street: Edward Hughes Ball Hughes, Regency dandy
- 51 Upper Brook Street: Giorgos Seferis — Greek Ambassador, poet and Nobel Laureate
- 56 Upper Brook Street: David Ricardo, economist.
- 13 Avery Row: W. H. Davies, Welsh tramp-poet.
- Survey of London, Volume 40: The Grosvenor Estate in Mayfair, Part 2 (The Buildings), 1980, ed. F. H. W. Sheppard, p. 210-221
- Brown, Susan, Patricia Clements, and Isobel Grundy, eds. Valentine Ackland entry: Life screen within Orlando: Women's Writing in the British Isles from the Beginnings to the Present. Cambridge: Cambridge University Press Online, 2006. http://orlando.cambridge.org/. 27 November 2018.
- 'Upper Brook Street: North Side', in Survey of London: Volume 40, the Grosvenor Estate in Mayfair, Part 2 (The Buildings), ed. F H W Sheppard (London, 1980), pp. 200-210 http://www.british-history.ac.uk/survey-london/vol40/pt2/pp200-210 Accessed 14 December 2015
- Wheatley, Henry Benjamin (1891). London, Past and Present. London: Murray. p. 283.