Anderson was born in Sacramento County, California and attended Clayton Valley High School in Concord, California. He was ridiculed for his curly hair, so he shaved it off in 1998 due to peer pressure. He later moved to Los Angeles to work with improvisational comedy troupes such as The Groundlings and Upright Citizens Brigade. While working as a pizza delivery driver, he attended Orange Coast College in Costa Mesa, where he met future co-star Adam DeVine.
In 2006, Anderson formed the sketch comedy group Mail Order Comedy with Anders Holm, Adam DeVine, and Kyle Newacheck. He appeared on several episodes of the Fox show Traffic Light and has had small cameos in an episode of HBO's Entourage. He was also in National Lampoon's The Legend of Awesomest Maximus (2009) and an episode of the Fox show House. He has appeared on many YouTube shows such as Mail Order Comedy (for which he writes and produces all of the material) and Dungeon of the Nutsack. He starred on the Comedy Central show Workaholics between 2011 and 2017. He has had roles on Community, Arrested Development, and Loiter Squad. He also tours the country to perform his stand-up comedy. In June 2016 it was announced that Anderson, Devine, Holm and Newacheck are working on a film with Seth Rogen as producer.
|2008||420 Special: Attack of the Show! from Jamaica||Limahl Spellswell||Television film|
|2009||Ratko: The Dictator's Son||Derek|
|2011||National Lampoon's 301: The Legend of Awesomest Maximus||Greek Soldier #1|
|2014||Neighbors||Beer Pong Guy #2||Cameo|
|2015||Scouts Guide to the Zombie Apocalypse||Ron the Janitor|
|2006–2008||Crossbows & Mustaches||10 episodes
|2008||Special Delivery||Himself||Episode: "Strike a Pose"|
|2008||The Dude's House||Anders||3 episodes
Co-creator, writer executive producer
|2008||5th Year||Anders||5 episodes|
|2011||Traffic Light||Tad||2 episodes|
|2011||Entourage||Donny||Episode: "One Last Shot"|
|2011||House||Ethan||Episode: "Perils of Paranoia"|
|2011–2017||Workaholics||Blake Henderson||Co-creator, writer, executive producer|
|2012||Community||Attendant||Episode: "Contemporary Impressionists"|
|2013||Arrested Development||B. Lake||Episode: "Flight of the Phoenix"|
|2014–2015||Parks and Recreation||Mike Bean||3 episodes|
|2014||The Eric André Show||Himself||1 episode|
|2015||Hell's Kitchen||Himself||Episode: "17 Chefs Compete"|
|2015||Comedy Bang! Bang!||Screggie's Real Father||Episode: "Karen Gillan Wears a Black and White Striped Pullover and Coral Skirt"|
|2015||Penn Zero: Part-Time Hero||Hogarth (voice)||Episode: "Boone's Apprentice"|
|2015||The Simpsons||Dickie (voice)||Episode: "Halloween of Horror"|
|2015||Drunk History||Alexey Leonov||Episode: "Space"|
|2016||Ice Age: The Great Egg-Scapade||Clint (voice)||TV short|
|2016||Voltron: Legendary Defender||Matt Holt (voice)||Episode: The Rise of Voltron, Return of the Gladiator and Tears of the Balmera"|
|2016||The Big Bang Theory||Trevor||Episode: "The Line Substitution Solution"|
|2016||Teenage Mutant Ninja Turtles: Don vs. Raph||Michelangelo (voice)||Short|
|2013||Major Lazer||"Scare Me"||Cyrus|
- "Bios". Mail Order Comedy. 2011-04-06. Retrieved 2012-09-02.
- "Blake Anderson's Bio". Comedy Central. Retrieved 17 September 2013.
- Rollo & Grandy (September 2, 2011). "Rollo & Grady Interview :: Blake Anderson of Workaholics". RolloGrandy.com. Retrieved 2013-09-30.
- "Workaholics Creators, Seth Rogen Team for Action Comedy 'Game Over, Man!". The Hollywood Reporter. June 6, 2016.
- Evers, Derek (2011-05-11). "Workaholic Blake Anderson | Bothering". Impose Magazine. Retrieved 2012-09-02.
- AMANDA MIKELBERG (2011-12-24). "WATCH: 'Workaholics' star fractures spine after jumping from roof - New York Daily News". Articles.nydailynews.com. Retrieved 2012-09-02.
- Durante, Thomas (2011-12-23). "'I got painkillers flowing... I'm all good': Workaholics star Blake Anderson breaks his back after plunging from roof onto beer pong table". London: Daily Mail. Retrieved 17 September 2013.
- PUBLIC RECORD. "image".
- Webber, Stephanie (2014-03-08). "Blake Anderson, Workaholics Star, Welcomes Baby Girl Mars Ilah With Wife Rachael Finley". Us Weekly.