Birnaviridae is a family of viruses[1]. Salmonid fish, young sexually immature chickens, and insects serve as natural hosts. There are currently six species in this family, divided among 4 genera.[2] Diseases associated with this family include: IPNV: infectious pancreatic necrosis in salmonid fish, causes significant losses to the aquaculture industry. chronic infection in adult, and acute viral disease in young salmonid fish.[2][3]

Virus classification e
(unranked): Virus
Realm: Riboviria
Phylum: incertae sedis
Family: Birnaviridae
Birnavirus RNA dependent RNA polymerase (VP1)
Birnavirus VP2 protein
PDB 2df7 EBI.jpg
crystal structure of infectious bursal disease virus vp2 subviral particle
Pfam clanCL0055
Birnavirus VP3 protein
Birnavirus VP4 protein
Birnavirus VP5 protein

Birnaviridae proteinsEdit

The Birnaviridae genome encodes several proteins:

Birnaviridae RNA-directed RNA polymerase (VP1), which lacks the highly conserved Gly-Asp-Asp (GDD) sequence, a component of the proposed catalytic site of this enzyme family that exists in the conserved motif VI of the palm domain of other RNA-directed RNA polymerases.[4]

The large RNA segment, segment A, of birnaviruses codes for a polyprotein (N-VP2-VP4-VP3-C) [5] that is processed into the major structural proteins of the virion: VP2, VP3 (a minor structural component of the virus), and into the putative protease VP4.[5] VP4 protein is involved in generating VP2 and VP3.[5] recombinant VP3 is more immunogenic than recombinant VP2.[6]

Infectious pancreatic necrosis virus (IPNV), a birnavirus, is an important pathogen in fish farms. Analyses of viral proteins showed that VP2 is the major structural and immunogenic polypeptide of the virus.[7][8] All neutralizing monoclonal antibodies are specific to VP2 and bind to continuous or discontinuous epitopes. The variable domain of VP2 and the 20 adjacent amino acids of the conserved C-terminal are probably the most important in inducing an immune response for the protection of animals.[7]

Non structural protein VP5 is found in RNA segment A.[citation needed] The function of this small viral protein is unknown. It is believed to be involved in influencing apoptosis, but studies are not completely concurring. The protein can not be found in the virion.


Viruses in Birnaviridae are non-enveloped, with icosahedral and Single-shelled geometries, and T=13 symmetry. The diameter is around 70 nm. Genomes are linear and segmented, around 15.2.3-3kb in length. The genome codes for 5 to 6 proteins.[2][3]

Genus Structure Symmetry Capsid Genomic arrangement Genomic segmentation
Avibirnavirus Icosahedral T=13 Non-enveloped Linear Segmented
Aquabirnavirus Icosahedral T=13 Non-enveloped Linear Segmented
Blosnavirus Icosahedral T=13 Non-enveloped Linear Segmented
Entomobirnavirus Icosahedral T=13 Non-enveloped Linear Segmented

Life cycleEdit

Viral replication is cytoplasmic. Entry into the host cell is achieved by penetration into the host cell. Replication follows the double-stranded RNA virus replication model. Double-stranded RNA virus transcription is the method of transcription. Salmonid fish, young sexually immature chickens, and insects serve as the natural host. Transmission routes are contact.[2][3]

Genus Host details Tissue tropism Entry details Release details Replication site Assembly site Transmission
Avibirnavirus Birds None Cell receptor endocytosis Budding Cytoplasm Cytoplasm Contact
Aquabirnavirus Salmonid fish None Cell receptor endocytosis Budding Cytoplasm Cytoplasm Contact
Blosnavirus Blotched snakehead fish None Unknown Budding Cytoplasm Cytoplasm Unknown
Entomobirnavirus Insects: diptera None Cell receptor endocytosis Budding Cytoplasm Cytoplasm Unknown


Group: dsRNA



  1. ^ Delmas, B; Attoui, H; Ghosh, S; Malik, YS; Mundt, E; Vakharia, VN; Ictv Report, Consortium (January 2019). "ICTV virus taxonomy profile: Birnaviridae". The Journal of General Virology. 100 (1): 5–6. doi:10.1099/jgv.0.001185. PMID 30484762.
  2. ^ a b c d e "Birnaviridae - Birnaviridae - dsRNA Viruses". International Committee on Taxonomy of Viruses (ICTV). Retrieved 16 October 2019.
  3. ^ a b c "Viral Zone". ExPASy. Retrieved 12 June 2015.
  4. ^ Shwed PS, Dobos P, Cameron LA, Vakharia VN, Duncan R (May 2002). "Birnavirus VP1 proteins form a distinct subgroup of RNA-dependent RNA polymerases lacking a GDD motif". Virology. 296 (2): 241–250. doi:10.1006/viro.2001.1334. PMID 12069523.
  5. ^ a b c Jagadish MN, Staton VJ, Hudson PJ, Azad AA (March 1988). "Birnavirus precursor polyprotein is processed in Escherichia coli by its own virus-encoded polypeptide". J. Virol. 62 (3): 1084–7. doi:10.1128/JVI.62.3.1084-1087.1988. PMC 253673. PMID 2828658.
  6. ^ Moon CH, Do JW, Cha SJ, Bang JD, Park MA, Yoo DJ, Lee JM, Kim HG, Chung DK, Park JW (October 2004). "Comparison of the immunogenicity of recombinant VP2 and VP3 of infectious pancreatic necrosis virus and marine birnavirus". Arch. Virol. 149 (10): 2059–68. doi:10.1007/s00705-004-0339-2. PMID 15669113.
  7. ^ a b Heppell J, Tarrab E, Lecomte J, Berthiaume L, Arella M (December 1995). "Strain variability and localization of important epitopes on the major structural protein (VP2) of infectious pancreatic necrosis virus". Virology. 214 (1): 40–9. doi:10.1006/viro.1995.9956. PMID 8525637.
  8. ^ Nobiron I, Galloux M, Henry C, Torhy C, Boudinot P, Lejal N, Da Costa B, Delmas B (February 2008). "Genome and polypeptides characterization of Tellina virus 1 reveals a fifth genetic cluster in the Birnaviridae family". Virology. 371 (2): 350–61. doi:10.1016/j.virol.2007.09.022. PMID 17976679.

External linksEdit