A biobank is a type of biorepository that stores biological samples (usually human) for use in research. Biobanks have become an important resource in medical research, supporting many types of contemporary research like genomics and personalized medicine.

Blood samples are collected from a newborn baby in Sweden for the national PKU registry biobank.

Biobanks can give researchers access to data representing a large number of people. Samples in biobanks and the data derived from those samples can often be used by multiple researchers for cross purpose research studies. For example, many diseases are associated with single-nucleotide polymorphisms. Genome-wide association studies using data from tens or hundreds of thousands of individuals can identify these genetic associations as potential disease biomarkers. Many researchers struggled to acquire sufficient samples prior to the advent of biobanks.

Biobanks have provoked questions on privacy, research ethics, and medical ethics. Viewpoints on what constitutes appropriate biobank ethics diverge. However, a consensus has been reached that operating biobanks without establishing carefully considered governing principles and policies could be detrimental to communities that participate in biobank programs.



The term "biobank" first appeared in the late 1990s and is a broad term that has evolved in recent years.[1][2] One definition is "an organized collection of human biological material and associated information stored for one or more research purposes."[3][4] Collections of plant, animal, microbe, and other nonhuman materials may also be described as biobanks but in some discussions the term is reserved for human specimens.[3]

Biobanks usually incorporate cryogenic storage facilities for the samples.[5] They may range in size from individual refrigerators to warehouses, and are maintained by institutions such as hospitals, universities, nonprofit organizations, and pharmaceutical companies.[5]

Biobanks may be classified by purpose or design. Disease-oriented biobanks usually have a hospital affiliation through which they collect samples representing a variety of diseases, perhaps to look for biomarkers affiliated with disease.[6][7] Population-based biobanks need no particular hospital affiliation because they take samples from large numbers of all kinds of people, perhaps to look for biomarkers for disease susceptibility in a general population.[8]

  • Virtual biobanks integrate epidemiological cohorts into a common pool.[9] Virtual biobanks allow for sample collection to meet national regulations.[10]
  • Tissue banks harvest and store human tissues for transplantation and research. As biobanks become more established, it is expected that tissue banks will merge with biobanks.[10]
  • Population banks store biomaterial as well as associated characteristics such as lifestyle, clinical, and environmental data.[10]

In 2008, United States researchers stored 270 million specimens in biobanks, and the rate of new sample collection was 20 million per year.[11] These numbers represent a fundamental worldwide change in the nature of research between the time when such numbers of samples could not be used and the time when researchers began demanding them.[11] Collectively, researchers began to progress beyond single-center research centers to a next-generation qualitatively different research infrastructure.[12] Some of the challenges raised by the advent of biobanks are ethical, legal, and social issues pertaining to their existence, including the fairness of collecting donations from vulnerable populations, providing informed consent to donors, the logistics of data disclosure to participants, the right to ownership of intellectual property, and the privacy and security of donors who participate.[11] Because of these new problems, researchers and policymakers began to require new systems of research governance.[12]

Many researchers have identified biobanking as a key area for infrastructure development in order to promote drug discovery and drug development.[3]

Types and applications


Human genetics research


By the late 1990s, scientists realized that although many diseases are caused at least in part by a genetic component, few diseases originate from a single defective gene; most genetic diseases are caused by multiple genetic factors on multiple genes.[13] Because the strategy of looking only at single genes was ineffective for finding the genetic components of many diseases, and because new technology made the cost of examining a single gene versus doing a genome-wide scan about the same, scientists began collecting much larger amounts of genetic information when any was to be collected at all.[13] At the same time technological advances also made it possible for wide sharing of information, so when data was collected, many scientists doing genetics work found that access to data from genome-wide scans collected for any one reason would actually be useful in many other types of genetic research.[13] Whereas before data usually stayed in one laboratory, now scientists began to store large amounts of genetic data in single places for community use and sharing.[13]

An immediate result of doing genome-wide scans and sharing data was the discovery of many single-nucleotide polymorphisms, with an early success being an improvement from the identification of about 10,000 of these with single-gene scanning and before biobanks versus 500,000 by 2007 after the genome-wide scanning practice had been in place for some years.[13] A problem remained; this changing practice allowed the collection of genotype data, but it did not simultaneously come with a system to gather the related phenotype data.[13] Whereas genotype data comes from a biological specimen like a blood sample, phenotype data has to come from examining a specimen donor with an interview, physical assessment, review of medical history, or some other process which could be difficult to arrange.[13] Even when this data was available, there were ethical uncertainties about the extent to which and the ways in which patient rights could be preserved by connecting it to genotypic data.[13] The institution of the biobank began to be developed to store genotypic data, associate it with phenotypic data, and make it more widely available to researchers who needed it.[13]

Biobanks including genetic testing samples have historically been composed of a majority of samples from individuals from European ancestry.[14] Diversification of biobank samples is needed and researchers should consider the factors effecting the underrepresented populations.[15][16]

Conservation, ecosystem restoration and geoengineering


In November 2020 scientists began collecting living fragments, tissue and DNA samples of the endangered corals from the Great Barrier Reef for a precautionary biobank for potential future restoration and rehabilitation activities.[17] A few months earlier another Australian team of researchers reported that they evolved such corals to be more heat-resistant.[18]

Biological specimens


The specimens stored by a biobank and made available to researchers are taken by sampling. Specimen types include blood, urine, skin cells, organ tissue, and other materials. Increasingly, methods for sampling tissue specimens are becoming more targeted, sometimes involving the use of MRI to determine which specific areas of tissue should be sampled.[19][20] The biobank keeps these specimens in good condition until a researcher needs them to conduct a test, do an experiment, or perform an analysis.[citation needed]



Biobanks, like other DNA databases, must carefully store and document access to samples and donor information.[21] The samples must be maintained reliably with minimal deterioration over time, and they must be protected from physical damage, both accidental and intentional. The registration of each sample entering and exiting the system is centrally stored, usually on a computer-based system that can be backed up frequently.[21] The physical location of each sample is noted to allow the rapid location of specimens. Archival systems de-identify samples to respect the privacy of donors and allow blinding of researchers to analysis.[21] The database, including clinical data, is kept separately with a secure method to link clinical information to tissue samples.[21] Room temperature storage of samples is sometimes used, and was developed in response to perceived disadvantages of low-temperature storage, such as costs and potential for freezer failure.[21] Current systems are small and are capable of storing nearly 40,000 samples in about one tenth of the space required by a −80 °C (−112 °F) freezer. Replicates or split samples are often stored in separate locations for security.[21]



One controversy of large databases of genetic material is the question of ownership of samples. As of 2007, Iceland had three different laws on ownership of the physical samples and the information they contain.[22] Icelandic law holds that the Icelandic government has custodial rights of the physical samples themselves while the donors retain ownership rights.[22] In contrast, Tonga and Estonia give ownership of biobank samples to the government, but their laws include strong protections of donor rights.[22]



The key event which arises in biobanking is when a researcher wants to collect a human specimen for research. When this happens, some issues which arise include the following: right to privacy for research participants, ownership of the specimen and its derived data, the extent to which the donor can share in the return of the research results, and the extent to which a donor is able to consent to be in a research study.[23]

With respect to consent, the main issue is that biobanks usually collect samples and data for multiple future research purposes and it is not feasible to obtain specific consent for all possible future research. It has been discussed that one-off consent or a broad consent for various research purposes may not suffice ethical and legal requirements.[24][25] Dynamic consent is an approach to consent that may be better suited to biobanking, because it enables ongoing engagement and communication between the researchers and sample/data donors over time.



There is no internationally accepted set of governance guidelines that are designed to work with biobanks. Biobanks typically try to adapt to the broader recommendations that are internationally accepted for human subject research and change guidelines as they become updated. For many types of research and particularly medical research, oversight comes at the local level from an institutional review board. Institutional review boards typically enforce standards set by their country's government. To different extents, the law used by different countries is often modeled on biobank governance recommendations that have been internationally proposed.

Key organizations


Some examples of organizations that participated in creating written biobanking guidelines are the following:[2] World Medical Association, Council for International Organizations of Medical Sciences, Council of Europe, Human Genome Organisation, World Health Organization, and UNESCO. The International Society for Biological and Environmental Repositories (ISBER) is a global biobanking organization which creates opportunities for networking, education, and innovations and harmonizes approaches to evolving challenges in biological and environmental repositories. ISBER connects repositories globally through best practices. The ISBER Best Practices, Fourth Edition was launched on January 31, 2018 with a LN2 addendum that was launched early May 2019.[26]



In 1998, the Icelandic Parliament passed the Act on Health Sector Database. This act allowed for the creation of a national biobank in that country. In 1999, the United States National Bioethics Advisory Commission issued a report containing policy recommendations about handling human biological specimens.[11] In 2005, the United States National Cancer Institute founded the Office of Biorepositories and Biospecimen Research so that it could have a division to establish a common database and standard operating procedures for its partner organizations with biospecimen collections.[11] In 2006, the Council of the European Union adopted a policy on human biological specimens, which was novel for discussing issues unique to biobanks.[11]



Researchers have called for a greater critical examination of the economic aspects of Biobanks, particularly those facilitated by the state.[27] National biobanks are often funded by public/private partnerships, with finance provided by any combination of national research councils, medical charities, pharmaceutical company investment, and biotech venture capital.[28] In this way, national biobanks enable an economic relationship mediated between states, national populations, and commercial entities. It has been illustrated that there is a strong commercial incentive underlying the systematic collection of tissue material. This can be seen particularly in the field of genomic research where population sized study lends itself more easily toward diagnostic technologies rather than basic etiological studies.[29] Considering the potential for substantial profit, researchers Mitchell and Waldby[27] argue that because biobanks enroll large numbers of the national population as productive participants, who allow their bodies and prospective medical histories to create a resource with commercial potential, their contribution should be seen as a form of "clinical labor" and therefore participants should also benefit economically.


There have been cases when the ownership of stored human specimens have been disputed and taken to court. Some cases include:

See also



  1. ^ Hewitt R, Watson P (October 2013). "Defining biobank". Biopreservation and Biobanking. 11 (5): 309–15. doi:10.1089/bio.2013.0042. PMID 24835262.
  2. ^ a b c Hewitt RE (January 2011). "Biobanking: the foundation of personalized medicine". Current Opinion in Oncology. 23 (1): 112–9. doi:10.1097/CCO.0b013e32834161b8. PMID 21076300. S2CID 205547716.
  3. ^ Kauffmann F, Cambon-Thomsen A (May 2008). "Tracing biological collections: between books and clinical trials". JAMA. 299 (19): 2316–8. doi:10.1001/jama.299.19.2316. PMID 18492973.
  4. ^ a b Silberman S (June 2010). "The Flesh Files". Wired. Vol. 18, no. 6. pp. 157–161, 182, 184, 188, 190.
  5. ^ Bevilacqua G, Bosman F, Dassesse T, Höfler H, Janin A, Langer R, et al. (April 2010). "The role of the pathologist in tissue banking: European Consensus Expert Group Report". Virchows Archiv. 456 (4): 449–54. doi:10.1007/s00428-010-0887-7. PMC 2852521. PMID 20157825.
  6. ^ Paskal W, Paskal AM, Dębski T, Gryziak M, Jaworowski J (October 2018). "Aspects of Modern Biobank Activity - Comprehensive Review". Pathology & Oncology Research. 24 (4): 771–785. doi:10.1007/s12253-018-0418-4. PMC 6132819. PMID 29728978.
  7. ^ Riegman PH, Morente MM, Betsou F, de Blasio P, Geary P, et al. (Marble Arch International Working Group on Biobanking for Biomedical Research) (October 2008). "Biobanking for better healthcare". Molecular Oncology. 2 (3): 213–22. doi:10.1016/j.molonc.2008.07.004. PMC 5527804. PMID 19383342.
  8. ^ Gottweis H, Petersen AR (20 June 2008). Biobanks: governance in comparative perspective. Taylor & Francis. p. 92. ISBN 978-0-415-42737-1. Retrieved 1 February 2012.
  9. ^ a b c Labant MA (Jan 15, 2012). "Biobank Diversity Facilitates Drug & Diagnostic Development". Genetic Engineering & Biotechnology News. 32 (2): 42,44. doi:10.1089/gen.32.2.21. ISSN 1935-472X. Retrieved 1 February 2012.
  10. ^ a b c d e f Haga S, Beskow L (2008). "Ethical, Legal, and Social Implications of Biobanks for Genetics Research". Genetic Dissection of Complex Traits. Advances in Genetics. Vol. 60. pp. 505–544. doi:10.1016/S0065-2660(07)00418-X. ISBN 9780123738837. PMID 18358331.
  11. ^ a b Fullerton SM, Anderson NR, Guzauskas G, Freeman D, Fryer-Edwards K (January 2010). "Meeting the governance challenges of next-generation biorepository research". Science Translational Medicine. 2 (15): 15cm3. doi:10.1126/scitranslmed.3000361. PMC 3038212. PMID 20371468.
  12. ^ a b c d e f g h i Greely HT (2007). "The uneasy ethical and legal underpinnings of large-scale genomic biobanks". Annual Review of Genomics and Human Genetics. 8: 343–64. doi:10.1146/annurev.genom.7.080505.115721. PMID 17550341.
  13. ^ Fisher ER, Pratt R, Esch R, Kocher M, Wilson K, Lee W, Zierhut HA (February 2020). "The role of race and ethnicity in views toward and participation in genetic studies and precision medicine research in the United States: A systematic review of qualitative and quantitative studies". Molecular Genetics & Genomic Medicine. 8 (2): e1099. doi:10.1002/mgg3.1099. PMC 7005620. PMID 31867882.
  14. ^ Ewing AT, Turner AD, Sakyi KS, Elmi A, Towson M, Slade JL, et al. (September 2020). "Amplifying Their Voices: Advice, Guidance, and Perceived Value of Cancer Biobanking Research Among an Older, Diverse Cohort". Journal of Cancer Education. 37 (3): 683–693. doi:10.1007/s13187-020-01869-0. PMC 10286728. PMID 32975747. S2CID 221917485.
  15. ^ Ewing AT, Kalu N, Cain G, Erby LH, Ricks-Santi LJ, Tetteyfio-Kidd Telemaque E, Scott DM (October 2019). "Factors associated with willingness to provide biospecimens for genetics research among African American cancer survivors". Journal of Community Genetics. 10 (4): 471–480. doi:10.1007/s12687-019-00411-0. PMC 6754482. PMID 30877487.
  16. ^ Lu D. "Biobank to house 800 coral species so we can restore reefs in future". New Scientist. Retrieved 9 December 2020.
  17. ^ "Scientists successfully develop 'heat resistant' coral to fight bleaching". phys.org. Retrieved 29 December 2020.
  18. ^ Heavey S, Haider A, Sridhar A, Pye H, Shaw G, Freeman A, Whitaker H (October 2019). "Use of Magnetic Resonance Imaging and Biopsy Data to Guide Sampling Procedures for Prostate Cancer Biobanking". Journal of Visualized Experiments (152). doi:10.3791/60216. PMID 31657791.
  19. ^ Heavey S, Costa H, Pye H, Burt EC, Jenkinson S, Lewis GR, et al. (May 2019). "PEOPLE: PatiEnt prOstate samPLes for rEsearch, a tissue collection pathway utilizing magnetic resonance imaging data to target tumor and benign tissue in fresh radical prostatectomy specimens". The Prostate. 79 (7): 768–777. doi:10.1002/pros.23782. PMC 6618051. PMID 30807665.
  20. ^ a b c d e f Macleod AK, Liewald DC, McGilchrist MM, Morris AD, Kerr SM, Porteous DJ (February 2009). "Some principles and practices of genetic biobanking studies". The European Respiratory Journal. 33 (2): 419–25. doi:10.1183/09031936.00043508. PMID 19181915. S2CID 6669308.
  21. ^ a b c Nwabueze RN (2007-09-30). Biotechnology and the Challenge of Property: Property Rights in Dead Bodies. Aldershot, England: Ashgate Press. pp. 169–170. ISBN 978-0-7546-7168-8.
  22. ^ Hawkins AK, O'Doherty KC (October 2011). ""Who owns your poop?": insights regarding the intersection of human microbiome research and the ELSI aspects of biobanking and related studies". BMC Medical Genomics. 4: 72. doi:10.1186/1755-8794-4-72. PMC 3199231. PMID 21982589.
  23. ^ Hoeyer K (2012). "Trading in Cold Blood?". Trust in Biobanking. pp. 21–41.
  24. ^ Ewing AT, Erby LA, Bollinger J, Tetteyfio E, Ricks-Santi LJ, Kaufman D (April 2015). "Demographic differences in willingness to provide broad and narrow consent for biobank research". Biopreservation and Biobanking. 13 (2): 98–106. doi:10.1089/bio.2014.0032. PMC 4574731. PMID 25825819.
  25. ^ "ISBER Best Practices For Repositories - ISBER". www.isber.org. Retrieved 2020-02-11.
  26. ^ a b Mitchell R (May 2010). "National Biobanks: Clinical Labor, Risk Production, and the Creation of Biovalue". Science, Technology, & Human Values. 35 (3): 330–355. doi:10.1177/0162243909340267. PMC 2879701. PMID 20526462.
  27. ^ Lewis G (2004). "Tissue collection and the pharmaceutical industry: investigating corporate biobanks.". In Tutton R, Corrigan O (eds.). Genetic databases: Socio-ethical issues in the collection and use of DNA. London and New York: Routledge. pp. 181–201.
  28. ^ Rajan KS (2006). Biocapital: The constitution of postgenomic life. Durham: Duke University Press.

Further reading