Benperidol, sold under the trade name Anquil among others, is a drug which is a highly potent butyrophenone derivative. It is the most potent neuroleptic on the European market, with chlorpromazine equivalency as high as 75 to 100 (about 150 to 200% potency in terms of dose compared to haloperidol). It is an antipsychotic, which can be used for the treatment of schizophrenia, but it is primarily used to control hypersexuality syndromes and is sometimes prescribed to sex offenders as a condition of their parole, as an alternative to anti-androgen drugs such as cyproterone acetate.
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|Molar mass||381.443 g/mol g·mol−1|
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Benperidol was discovered at Janssen Pharmaceutica in 1961.
- "Benperidol - a drug for sexual offenders?". Drug and Therapeutics Bulletin. BMJ Publishing Group Ltd. 12: 12. 1974-02-01.
- Möller; Müller; Bandelow: Neuroleptika, 2001, WVG; ISBN 3-8047-1773-X (in German)
- Bobon J, Collard J, Lecoq R, Benperidol and promazine: a "double blind" comparative study in mental geriatrics, Acta Neurol Belg. 1963 Oct;63:839-43.
- British National Formulary (49th), British Medical Association 2005 p 183
- Murray MA, Bancroft JH, Anderson DC, Tennent TG, Carr PJ., Endocrine changes in male sexual deviants after treatment with anti-androgens, oestrogens or tranquillizers, Journal of Endocrinology. 1975 Nov;67(2):179-88.
- BE 626307 (1963 to Janssen), C.A. 60, 10690c (1964), corresp. to GB 989755 .
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