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Lys-63-specific deubiquitinase BRCC36 is an enzyme that in humans is encoded by the BRCC3 gene.[5][6][7]

BRCC3
Identifiers
AliasesBRCC3, BRCC36, C6.1A, CXorf53, BRCA1/BRCA2-containing complex subunit 3
External IDsMGI: 2389572 HomoloGene: 11530 GeneCards: BRCC3
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for BRCC3
Genomic location for BRCC3
BandXq28Start155,071,420 bp[1]
End155,123,074 bp[1]
RNA expression pattern
PBB GE BRCC3 216521 s at fs.png

PBB GE BRCC3 221196 x at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001018055
NM_001242640
NM_024332

NM_001166457
NM_001166459
NM_145956
NM_001358736
NM_001358737

RefSeq (protein)

NP_001018065
NP_001229569
NP_077308

NP_001159929
NP_001159931
NP_666068
NP_001345665
NP_001345666

Location (UCSC)Chr X: 155.07 – 155.12 MbChr X: 75.42 – 75.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Contents

FunctionEdit

This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint. Alternative splicing results in multiple transcript variants.[7]

InteractionsEdit

BRCC3 has been shown to interact with BRE,[6][8] BRCA2,[6] RAD51,[6] BRCA1,[6] P53[6] and BARD1.[6]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185515 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031201 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Kenwrick S, Levinson B, Taylor S, Shapiro A, Gitschier J (Jun 1992). "Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene". Human Molecular Genetics. 1 (3): 179–86. doi:10.1093/hmg/1.3.179. PMID 1303175.
  6. ^ a b c d e f g Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK, Shiekhattar R (Nov 2003). "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair". Molecular Cell. 12 (5): 1087–99. doi:10.1016/S1097-2765(03)00424-6. PMID 14636569.
  7. ^ a b "Entrez Gene: BRCC3 BRCA1/BRCA2-containing complex, subunit 3".
  8. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External linksEdit

Further readingEdit