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Anthony Rex Hunter (born 23 August 1943) is a British-American biologist who is a Professor of Biology at the Salk Institute for Biological Studies and the University of California San Diego. His research publications list his name as Tony Hunter.[6]

Tony Hunter
Tony Hunter.jpg
Anthony Rex Hunter
Born
Anthony Rex Hunter

(1943-08-23) 23 August 1943 (age 75)
United Kingdom
NationalityBritish
Alma mater
Known forKinases[1]
Awards
Scientific career
FieldsBiology
Institutions
ThesisAspects of mammalian protein synthesis (1969)
Doctoral advisorAsher Korner[2]
Notable studentsJonathon Pines (postdoc)[3][4][5]
Websitewww.salk.edu/scientist/tony-hunter/

Contents

Early life and educationEdit

Hunter was born in 1943 in the United Kingdom and educated at Felsted School, prior to Christ's College, Cambridge where he was awarded a PhD in 1969 for research on protein synthesis.[7]

Career and researchEdit

Following his PhD, Hunter held a fellowship at Christ's College, Cambridge in Cambridge (1968–1971) and (1973–1975). From 1971 to 1973, he was a postdoctoral research associate of the Salk Institute for Biological Studies in La Jolla, California. He was then assistant professor 1975–78, associate professor 1978–82, professor 1982 onwards and since 2008 director of the Salk Institute Cancer Center.[8] He also sits on the Selection Committee for Life Science and Medicine which chooses winners of the Shaw Prize.

Hunter is one of the foremost recognized leaders in the field of cell growth control, growth factor receptors and their signal transduction pathways. He is well known for discovering that tyrosine phosphorylation is a fundamental mechanism for transmembrane-signal transduction in response to growth factor stimulation and that disregulation of such tyrosine phosphorylation, by activated oncogenic protein tyrosine kinases,[1] is a pivotal mechanism utilized in the malignant transformation of cells. His work is important in signaling pathways and their disorders.

Hunter was a founder of Signal Pharmaceuticals.[citation needed]

Awards and honorsEdit

He won the Wolf Prize in Medicine in 2005 for "the discovery of protein kinases that phosphorylate tyrosine residues in proteins, critical for the regulation of a wide variety of cellular events, including malignant transformation".[9] He has been granted along with Charles Sawyers and Joseph Schlessinger with the 2014 BBVA Foundation Frontiers of Knowledge Award in the Biomedicine category for “carving out the path that led to the development of a new class of successful cancer drugs.”

ReferencesEdit

  1. ^ a b Hunter, Tony (May 2008). "Tony Hunter: kinase king. Interview by Ruth Williams". J. Cell Biol. 181 (4): 572–3. doi:10.1083/jcb.1814pi. PMC 2386096. PMID 18490508.
  2. ^ http://hunter.salk.edu/people.php
  3. ^ Pines, Jonathon; Hunter, Tony (1990). "Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B". Nature. 346 (6286): 760–763. doi:10.1038/346760a0. PMID 2143810.
  4. ^ Hunter, Tony; Pines, Jonathon (1991). "Cyclins and cancer". Cell. 66 (6): 1071–1074. doi:10.1016/0092-8674(91)90028-W.
  5. ^ Hunter, Tony; Pines, Jonathan (1994). "Cyclins and cancer II: Cyclin D and CDK inhibitors come of age". Cell. 79 (4): 573–582. doi:10.1016/0092-8674(94)90543-6.
  6. ^ Bailis, J. M.; Luche, D. D.; Hunter, T.; Forsburg, S. L. (2008). "Minichromosome Maintenance Proteins Interact with Checkpoint and Recombination Proteins to Promote S-Phase Genome Stability". Molecular and Cellular Biology. 28 (5): 1724–1738. doi:10.1128/MCB.01717-07. PMC 2258774. PMID 18180284.
  7. ^ Hunter, Anthony Rex (1969). Aspects of mammalian protein synthesis (PhD thesis). University of Cambridge. OCLC 500479081.
  8. ^ "Tony Hunter FRS". Debretts. Retrieved 18 July 2010.
  9. ^ "The Wolf Prize in Medicine". Archived from the original on 26 February 2009. Retrieved 2010-04-29.CS1 maint: BOT: original-url status unknown (link). wolffund.org.il
  10. ^ "Lists of Royal Society Fellows 1660–2007". London: Royal Society. Archived from the original on 24 March 2010. Retrieved 18 July 2010.
  11. ^ National Academy of Science Member Directory. Retrieved on 2017-12-08.
  12. ^ The Keio Medical Science Prize. Ms-fund.keio.ac.jp. Retrieved on 2013-10-08.
  13. ^ Tony Hunter at The Salk Institute. Biology.ucsd.edu. Retrieved on 2013-10-08.
  14. ^ Tony Hunter Receives Pasarow Award for Cancer Research. Salk Institute for Biological Studies (2011)
  15. ^ Salk scientist awarded inaugural Sjöberg Prize for cancer breakthrough. Salk.edu. Retrieved on 2017-03-02.