He is not to be confused with his better known great-grandfather Alexander Farnese, Duke of Parma. This Alessandro was often called Alessandro di Odoardo (son of Odoardo).
He became governor of the Southern Netherlands after the Franco-Dutch War.
Alexander died in Madrid in 1689.
By his mistress Maria de Lao y Carillo had the following children:
- Alessandro Odoardo (Badajoz, 12 April 1663 – Cacéres, 21 May 1666)
- Alessandro Maria (Badajoz, 30 October 1664 – 28 September 1726), Colonel in Spanish army
- Margherita (Badajoz, 5 June 1665 – Parma, November 1718), nun in Parma
- Isabella (Badajoz, 19 September 1666 – Parma, 27 December 1741), nun in Parma