|, AGSW, AGTI, AGTIL, ASP, SHEP9, agouti signaling protein|
Agouti signalling peptide is a peptide consisting of 131 amino acids. Its discovery was published in 1994 in the scientific journal Nature where its functional properties were described. It acts as an inverse agonist at melanocortin receptors.
In mice, the agouti gene encodes a paracrine signalling molecule that causes hair follicle melanocytes to synthesize the yellow pigment pheomelanin instead of the black or brown pigment eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as an inverse agonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes.
- GRCh38: Ensembl release 89: ENSG00000101440 - Ensembl, May 2017
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- Lu D, Willard D, Patel IR, Kadwell S, Overton L, Kost T, Luther M, Chen W, Woychik RP, Wilkison WO (October 1994). "Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor". Nature. 371 (6500): 799–802. Bibcode:1994Natur.371..799L. doi:10.1038/371799a0. PMID 7935841.
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- McNulty JC, Jackson PJ, Thompson DA, Chai B, Gantz I, Barsh GS, Dawson PE, Millhauser GL (2005). "Structures of the agouti signaling protein". Journal of Molecular Biology. 346 (4): 1059–1070. doi:10.1016/j.jmb.2004.12.030. PMID 15701517.