It passes through Indian cities of Agra (AH1), Gwalior (AH47), Nagpur (AH46), Hyderabad and Bangalore (AH45, AH47), Madurai. The road briefly ends at Rameswaram before starting in Sri Lanka at Talaimannar and passes through Mannar, Anuradhapura, Dambulla (AH44), Kurunegala, Kandy, Colombo, Galle and Matara.
The route shares some portions of various Indian National Highways: NH 3, NH 75, NH 26, NH 44 and NH 49. Various cities and towns are situated along AH43 in the Indian states of Uttar Pradesh, Rajasthan, Madhya Pradesh, Maharashtra, Telangana, Andhra Pradesh, Karnataka, and Tamil Nadu.
The route shares portions of the following Sri Lankan highways:
- Economic and Social Commission for Asia and the Pacific, 2003 Asian Highway Handbook Archived 2012-04-14 at the Wayback Machine., 2003, page 41
- Economic and Social Commission for Asia and the Pacific, 2003 Asian Highway Handbook Archived 2012-04-14 at the Wayback Machine., 2003, page 98
- http://www.unescap.org/ttdw/common/TIS/AH/files/wgm4/Countries/Status/SriLanka.pdf[permanent dead link] Status Paper on Asian Highway Sri Lanka