Year 541 (DXLI) was a common year starting on Tuesday (link will display the full calendar) of the Julian calendar. At the time, it was known as the Year of the Consulship of Basilius without colleague (or, less frequently, year 1294 Ab urbe condita). Basilius was the last person to be officially appointed Roman consul, since after this year, the office was permanently merged with the office of Roman/Byzantine emperor. Thus, from the next year forward, the consular year dating was abandoned. The denomination 541 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years.
|Ab urbe condita||1294|
|Balinese saka calendar||462–463|
|Chinese calendar||庚申年 (Metal Monkey)|
3237 or 3177
— to —
辛酉年 (Metal Rooster)
3238 or 3178
|- Vikram Samvat||597–598|
|- Shaka Samvat||462–463|
|- Kali Yuga||3641–3642|
|Iranian calendar||81 BP – 80 BP|
|Islamic calendar||84 BH – 83 BH|
|Minguo calendar||1371 before ROC|
|Seleucid era||852/853 AG|
|Thai solar calendar||1083–1084|
667 or 286 or −486
— to —
668 or 287 or −485
- January 1 – Anicius Faustus Albinus Basilius is appointed as consul in Constantinople, the last person to hold this office.
- Plague of Justinian: Bubonic plague appears suddenly in the Egyptian port of Pelusium, spreading to Alexandria and, the following year, to Constantinople. This is the beginning of a 200-year-long pandemic that will devastate Europe, the Middle East, and North Africa.
- Emperor Justinian I recalls Belisarius from Italy to handle the situation in Armenia. He arrives in Upper Mesopotamia and attacks the fortress city of Nisbis. After an unsuccessful siege he ravages the countryside.
- John the Cappadocian, praetorian prefect of the East, is dismissed by the Byzantine empress Theodora for treason. He is banished to Cyzicus, and his estates are confiscated.
- Autumn – Totila is elected king by the Ostrogothic nobles after the death of his uncle Ildibad. He wins the support of the lower classes by liberating slaves and distributing land to the peasants.
- Winter – Siege of Verona: Totila defends the city of Verona against a numerically superior Byzantine army. He gains control over the Po Valley and prepares a Gothic offensive in Central Italy.
- Lazic War: King Khosrau I intervenes in Lazica (modern Georgia), and supports the weakened king Gubazes II against a full-scale uprising. He sends an expeditionary force under Mermeroes and captures the Byzantine stronghold of Petra, located on the coast of the Black Sea, which provides the Persians a strategic port.