60S ribosomal protein L23a

60S ribosomal protein L23a is a protein that in humans is encoded by the RPL23A gene.[3][4]

RPL23A
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesRPL23A, L23A, MDA20, ribosomal protein L23a
External IDsOMIM: 602326 HomoloGene: 133569 GeneCards: RPL23A
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for RPL23A
Genomic location for RPL23A
Band17q11.2Start28,719,985 bp[1]
End28,724,359 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000984

n/a

RefSeq (protein)

NP_000975

n/a

Location (UCSC)Chr 17: 28.72 – 28.72 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

FunctionEdit

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family of ribosomal proteins. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[4]

Clinical significanceEdit

L23a has been identified as an autoimmune target that causes a form of rheumatoid arthritis in mice and which also causes a reaction from T cells and autoantibodies from human rheumatoid arthritis patients.[5]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198242 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Fan W, Christensen M, Eichler E, Zhang X, Lennon G (Feb 1998). "Cloning, sequencing, gene organization, and localization of the human ribosomal protein RPL23A gene". Genomics. 46 (2): 234–9. doi:10.1006/geno.1997.5038. PMID 9417910.
  4. ^ a b "Entrez Gene: RPL23A ribosomal protein L23a".
  5. ^ Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali DA, Kappler JW, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S (2014). "Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease". Science. 346 (6207): 363–8. doi:10.1126/science.1259077. PMC 5554397. PMID 25324392.

Further readingEdit

External linksEdit

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human 60S ribosomal protein L23a