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3-oxo-5α-steroid 4-dehydrogenase 2 is an enzyme that in humans is encoded by the SRD5A2 gene.[5][6] It is one of three forms of 5α-reductase.

SRD5A2
Identifiers
AliasesSRD5A2, entrez:6716, steroid 5 alpha-reductase 2
External IDsOMIM: 607306 MGI: 2150380 HomoloGene: 37292 GeneCards: SRD5A2
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for SRD5A2
Genomic location for SRD5A2
Band2p23.1Start31,522,480 bp[1]
End31,580,938 bp[1]
RNA expression pattern
PBB GE SRD5A2 206938 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000348

NM_053188

RefSeq (protein)

NP_000339

NP_444418

Location (UCSC)Chr 2: 31.52 – 31.58 MbChr 17: 74.02 – 74.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Steroid 5α-reductase catalyzes the conversion of the male sex hormone testosterone into the more potent androgen, dihydrotestosterone.

This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).[6]

See alsoEdit

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000277893 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038541 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Thigpen AE, Davis DL, Milatovich A, Mendonca BB, Imperato-McGinley J, Griffin JE, Francke U, Wilson JD, Russell DW (Oct 1992). "Molecular genetics of steroid 5 alpha-reductase 2 deficiency". J Clin Invest. 90 (3): 799–809. doi:10.1172/JCI115954. PMC 329933. PMID 1522235.
  6. ^ a b "Entrez Gene: SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)".

Further readingEdit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.