Year 421 BC was a year of the pre-Julian Roman calendar. At the time, it was known in Rome as the Year of the Consulship of Vibulanus and Barbatus (or, less frequently, year 333 Ab urbe condita). The denomination 421 BC for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years.
|Millennium:||1st millennium BC|
|Gregorian calendar||421 BC|
|Ab urbe condita||333|
|Ancient Egypt era||XXVII dynasty, 105|
|- Pharaoh||Darius II of Persia, 3|
|Ancient Greek era||89th Olympiad, year 4|
|Balinese saka calendar||N/A|
|Chinese calendar||己未年 (Earth Goat)|
2276 or 2216
— to —
庚申年 (Metal Monkey)
2277 or 2217
|Coptic calendar||−704 – −703|
|Ethiopian calendar||−428 – −427|
|- Vikram Samvat||−364 – −363|
|- Shaka Samvat||N/A|
|- Kali Yuga||2680–2681|
|Iranian calendar||1042 BP – 1041 BP|
|Islamic calendar||1074 BH – 1073 BH|
|Minguo calendar||2332 before ROC|
|Thai solar calendar||122–123|
−294 or −675 or −1447
— to —
−293 or −674 or −1446
- Nicias, the leader of the aristocratic and peace party in Athens and Pleistoanax, King of Sparta, negotiate the Peace of Nicias between Athens and Sparta, which brings a temporary end to the Peloponnesian War. The essence of the Peace of Nicias is a return to the antebellum period with most wartime gains being returned. Seventeen representatives from each side swear an oath to uphold the treaty, which is meant to last for one generation (30 years: meaning they are not responsible for the next generation's decision). All of Sparta's allies agree to sign the peace except for the Boeotians, Corinth, Elis, and Megara.
- Alcibiades engineers an anti-Spartan alliance between Athens and the democracies of Argos, Mantinea and Elis.
- The construction of the Porch of the Maidens (the Caryatid Porch) commences at the Erechtheion which is part of the Acropolis in Athens.