4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
|4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase|
|PDB structures||RCSB PDB PDBe PDBsum|
|Gene Ontology||AmiGO / QuickGO|
- 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + protein-dithiol (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + protein-disulfide
The substrate of this enzyme is 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEcPP) and the product is (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate (HMB-PP). Electrons are donated by two reduced ferredoxin proteins per reaction.
This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 groups with a disulfide as acceptor. The systematic name of this enzyme class is (E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating).
- Hecht S, Eisenreich W, Adam P, Amslinger S, Kis K, Bacher A, Arigoni D, Rohdich F (December 2001). "Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein". Proceedings of the National Academy of Sciences of the United States of America. 98 (26): 14837–42. doi:10.1073/pnas.201399298. PMC 64945. PMID 11752431.