Fourteen teams contested the 1999–2000 edition of the league. The first team in the league, Al Ahly, were crowned the champions, and qualified for the first round of the CAF Champions League in 2000 along with the team finishing in second place. Third placed team qualified to confederation cup. Finally, the last three in the league will play next season in the second division .
| Season | 1999–2000 |
|---|---|
| Champions | Al Ahly |
| Relegated | |
| CAF Champions League |
|
| CAF Cup | Zamalek SC (3rd) |
| Top goalscorer |  John Utaka (17 goals) |
← 1998–99 2000–01 → | |
League table edit
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification or relegation |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Al Ahly (C) | 26 | 18 | 6 | 2 | 41 | 14 | +27 | 60 | 2001 CAF Champions League |
| 2 | Ismaily | 26 | 17 | 3 | 6 | 53 | 22 | +31 | 54 | |
| 3 | Zamalek SC | 26 | 14 | 10 | 2 | 48 | 23 | +25 | 52 | 2001 CAF Cup |
| 4 | El Mansoura SC | 26 | 11 | 5 | 10 | 33 | 30 | +3 | 38 | |
| 5 | El Mokawloon SC | 26 | 9 | 9 | 8 | 25 | 22 | +3 | 36 | |
| 6 | Mazarea Dina FC | 26 | 8 | 11 | 7 | 27 | 28 | −1 | 35 | |
| 7 | Al Masry | 26 | 8 | 9 | 9 | 25 | 25 | 0 | 33 | |
| 8 | Goldi SC | 26 | 8 | 9 | 9 | 28 | 31 | −3 | 33 | |
| 9 | El Qanah FC | 26 | 8 | 9 | 9 | 22 | 25 | −3 | 33 | |
| 10 | Al Ittihad Alexandria Club | 26 | 7 | 10 | 9 | 19 | 27 | −8 | 31 | |
| 11 | Koroum | 26 | 7 | 8 | 11 | 28 | 28 | 0 | 29 | |
| 12 | Suez SC | 26 | 6 | 9 | 11 | 14 | 35 | −21 | 27 | Relegation to Egyptian Second Division |
| 13 | Aluminium Nag Hammâdi | 26 | 4 | 4 | 18 | 18 | 39 | −21 | 16 | |
| 14 | El Sharkia SC | 26 | 3 | 6 | 17 | 22 | 54 | −32 | 15 |