The year 1968 in art involved some significant events and new works.
- March 5 – Musical chess match between Marcel Duchamp and John Cage takes place at Ryerson Polytechnic, Toronto.
- May 2 – Christ Church Picture Gallery in Oxford, England, designed by Powell and Moya, is opened.
- June 3 – Radical feminist Valerie Solanas shoots Andy Warhol at his New York City studio, The Factory; he survives after a 5-hour operation.
- July 17 – Release of the animated musical fantasy film Yellow Submarine in the United Kingdom, directed by George Dunning with art direction by Heinz Edelmann.
- August 20 – The National Gallery of Victoria in Melbourne, Australia, designed by Sir Roy Grounds, is opened.
- September 15 – The Neue Nationalgalerie in West Berlin, Germany, designed by Mies van der Rohe, is opened.
- November 7 – New building for the São Paulo Museum of Art (MASP) in Brazil, designed by Lina Bo Bardi, is inaugurated.
- Rubens' The Adoration of the Magi (1634) is installed as an altarpiece at King's College Chapel, Cambridge.
- February 11 – Jacob Steinhardt, German-born Jewish painter and woodcut artist (born 1887)
- April 26 – John Heartfield, German graphic designer (born 1891)
- May 9 – Harold Gray, American cartoonist, created Little Orphan Annie (born 1894)
- May 21 – Bror Hjorth, Swedish sculptor (born 1894)
- May 28 – Kees van Dongen, Dutch Fauvist painter (born 1877)
- June 17 – Cassandre, French graphic designer (born 1901)
- July 2 – Sir Hans Heysen, German-born Australian watercolour painter (born 1877)
- July 16 – William John Leech, Irish painter (born 1881)
- August 8 – Orovida Pissarro, English painter and etcher (born 1893)
- October 2 – Marcel Duchamp, influential French artist (born 1887)
- November – Lee Gatch, American painter and mixed-media artist (born 1902)
- November 4 – Michel Kikoine, Litvak-born French painter (born 1892)
- date unknown