October 1 Alabama defeated Samford 34–0, Fordham beat Upsala 47–0, Dartmouth beat St Lawrence 51–0, and Notre Dame beat Kansas 52–0. Pitt defeated Temple 28–6, California beat Washington State 27–3, and Minnesota beat Nebraska 16–7.
October 8 Minnesota defeated Purdue 7–0. Alabama beat North Carolina State 14–0. Dartmouth stayed unscored upon, winning at Princeton 22–0. Pittsburgh beat cross-town rival Duquesne 27–0. Fordham beat Waynesburg College 53–0. California played a double-header for the fans, with the reserves beating the California Agricultural school (lager UC-Davis) 48–0, and the varsity and reserves beating College of the Pacific 39–0. In Atlanta, Notre Dame beat Georgia Tech 14–6.
October 15 Pittsburgh won at Wisconsin 26–6. California defeated UCLA 20–7. Dartmouth beat Brown 34–13, and Notre Dame beat Illinois 14–6. Minnesota edged Michigan, 7–6. Fordham was tied by Purdue 6–6, and in Birmingham, Alabama was shut out by Tennessee, 13–0. When the first round of balloting was finished, the defending champion Panthers were again No. 1, followed by Minnesota, California, Dartmouth, and Notre Dame.
October 22 No. 1 Pittsburgh beat SMU 34–7. No. 2 Minnesota was idle. No. 3 California won at Seattle over Washington 14–7. No. 4 Dartmouth won at Harvard 13–7. No. 5 Notre Dame beat No. 13 Carnegie Tech 7–0. No. 6 Santa Clara beat Arkansas 21–6 in San Francisco, while in Milwaukee, No. 7 TCU beat Marquette 21–0, and the two winners replaced Dartmouth and Notre Dame in the Top Five: No. 1 Pittsburgh, No. 2 Minnesota, No. 3 California, No. 4 TCU, and No. 5 Santa Clara.
No. 1 Pittsburgh beat No. 9 Fordham, 24–13. No. 2 Minnesota fell to No. 12 Northwestern, 6–3. No. 3 California beat Oregon State 13–7. No. 4 TCU beat Baylor 39–7, and No. 5 Santa Clara won at Michigan State 7–6. No. 6 Dartmouth won at Yale 24–6 and No. 7 Notre Dame beat Army in Yankee Stadium, 19–7, and both returned to the Top Five: No. 1 Pittsburgh, No. 2 TCU, No. 3 California, No. 4 Notre Dame, and No. 5 Dartmouth.
November 5 In Pittsburgh, the No. 1 Panthers lost to No. 19 Carnegie Tech, 20–10. No. 2 TCU won at Tulsa 21–0. No. 3 California lost at No. 13 USC 13–7. In Baltimore, No. 4 Notre Dame beat Navy 15–0. No. 5 Dartmouth beat Dickinson College, 44–6. No. 6 Tennessee beat Chattanooga 45–0 to extend its record to 7–0–0. The Horned Frogs of TCU leaped into the top spot, ahead of Notre Dame, Pittsburgh, Tennessee, and Dartmouth.
November 12 No. 1 TCU beat Texas 28–6. No. 2 Notre Dame beat No. 12 Minnesota 19–0. No. 3 Pittsburgh beat Nebraska 19–0. No. 4 Tennessee won at Vanderbilt 14–0. No. 5 Dartmouth lost at No. 20 Cornell 14–7. No. 7 Duke remained unbeaten (7–0–0), untied, and unscored upon with a 21–0 win at Syracuse. In the next poll, the Irish moved up to the top rung, followed by TCU, Tennessee, Duke, and Pittsburgh.
November 19 No. 1 Notre Dame won at No. 16 Northwestern 9–7. No. 2 TCU won at Rice 29–7. No. 3 Tennessee was idle as it prepared for a holiday game. No. 4 Duke beat N.C. State, 7–0. No. 5 Pittsburgh beat Penn State 26–0. The rankings shuffled to No. 1 Notre Dame, No. 2 TCU, No. 3 Duke, No. 4 Pittsburgh, and No. 5 Tennessee.
On Thanksgiving Day No. 5 Tennessee beat Kentucky 46–0, while No. 6 Oklahoma beat Oklahoma A&M 19-0. Two days later, November 26, No. 1 Notre Dame remained idle. No. 2 TCU beat SMU in Dallas, 20–7. No. 3 Duke and
No. 4 Pittsburgh met at Durham, with the hosts winning 7–0. With a record of 9–0–0, Duke had outscored its opponents 114–0, but stayed in third in the next set of rankings: No. 1 Notre Dame, No. 2 TCU, No. 3 Duke, No. 4 Tennessee, and No. 5 Oklahoma.
On December 3, No. 1 Notre Dame lost in Los Angeles to No. 8 USC, 13–0, and fell from grace to fifth place. Previously No. 2-ranked TCU received 55 first place votes in the final poll and, as national champion, accepted a bid to the Sugar Bowl. No. 4 Tennessee beat Ole Miss 47–0 in Memphis, and moved up to second place. Though the SEC champion would be Sugar Bowl bound in later years, a No. 1 vs. No. 2 match was not to be had, as Tennessee instead took a bid for the Orange Bowl. No. 3 Duke stayed in third place, despite having never been scored upon in 1938, and accepted an invitation to the Rose Bowl. No. 5 Oklahoma beat Washington State 28–0 and moved up to fourth place. Both unbeaten and untied at 10–0–0, Tennessee and Oklahoma would meet in Miami, but the title had been awarded to 10–0–0 TCU.