Events from the year 1546 in art.
- Domenico Beccafumi – Pagan Child Couple
- Jacopo Bassano – The Adoration of the Shepherds
- Girolamo Siciolante da Sermoneta – Holy Family with Saint Michael
- Lorenzo Lotto – San Giacomo dell'Orio Altarpiece
- William Scrots
- Titian – Pope Paul III and his Grandsons
- January 4 - Camillo Boccaccino, Italian painter active mainly in Cremona and regions of Lombardy (born 1504)
- January 11 - Gaudenzio Ferrari, Italian painter and sculptor of the Renaissance (born 1471)
- August 1 - Peter Faber (or Pierre Favre), French Jesuit painter and sculptor (born 1506)
- October 23 - Peter Flötner, German designer, sculptor, and printmaker (born 1490)
- November 1 - Giulio Romano, Italian painter and architect (born 1499)
- date unknown
- probable - Marinus van Reymerswaele, Dutch Renaissance painter (born 1490
- Chronicled by Ulisse Aldrovandi (1556).