- Geoffrey Zakarian (born 1959), American restaurateur, television personality and author of Armenian origin
- Michel Der Zakarian, (born 1963), Franco-Armenian professional football player and later manager
- Ruth Zakarian (born 1966), Armenian-American winner of the first ever Miss Teen USA pageant
- Zakar Zakarian (1849-1923), French-Armenian painter
- Garbis Zakaryan, (born 1930), Turkish and European welterweight boxing champion of Armenian origin
- Lusine Zakaryan (1937-1992), an Armenian soprano singer
- Vanik Zakaryan or Zakharyan (born 1936), Armenian scientist
- Vardan Zakaryan, German amateur boxer of Armenian descent
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