Z30 small nucleolar RNA

      Z30 small nucleolar RNA
      RF00288.jpg
      Predicted secondary structure and sequence conservation of snoZ30
      Identifiers
      Symbol snoZ30
      Alt. Symbols Z30
      Rfam RF00288
      Other data
      RNA type Gene; snRNA; snoRNA; CD-box
      Domain(s) Eukaryota
      GO 0006396 0005730
      SO 0000593

      Z30 small nucleolar RNA, also known as SNORD7, is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. Z30 snoRNA belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]

      References

      1. ^ Galardi, Silvia; Fatica, Alessandro; Bachi, Angela; Scaloni, Andrea; Presutti, Carlo; Bozzoni, Irene (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.  edit
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      Last modified on 5 December 2012, at 15:48