These hits topped the Ultratop 50 in 2000.[1]
| Date | Artist | Title |
|---|---|---|
| January 1 | R. Kelly | "If I Could Turn Back the Hands of Time" |
| January 8 | R. Kelly | "If I Could Turn Back the Hands of Time" |
| January 15 | R. Kelly | "If I Could Turn Back the Hands of Time" |
| January 22 | Bloodhound Gang | "The Bad Touch" |
| January 29 | Bloodhound Gang | "The Bad Touch" |
| February 5 | Bloodhound Gang | "The Bad Touch" |
| February 12 | Bloodhound Gang | "The Bad Touch" |
| February 19 | Bloodhound Gang | "The Bad Touch" |
| February 26 | Metallica, Michael Kamen, and the San Francisco Symphony Orchestra | "Nothing Else Matters" |
| March 4 | Metallica, Michael Kamen, and The San Francisco Symphony Orchestra | "Nothing Else Matters" |
| March 11 | Metallica, Michael Kamen, and The San Francisco Symphony Orchestra | "Nothing Else Matters" |
| March 18 | Da Boy Tommy | "Candyman" |
| March 25 | Da Boy Tommy | "Candyman" |
| April 1 | Da Boy Tommy | "Candyman" |
| April 8 | Da Boy Tommy | "Candyman" |
| April 15 | Bomfunk MC's | "Freestyler" |
| April 22 | Bomfunk MC's | "Freestyler" |
| April 29 | Bomfunk MC's | "Freestyler" |
| May 6 | Bomfunk MC's | "Freestyler" |
| May 13 | Bomfunk MC's | "Freestyler" |
| May 20 | Bomfunk MC's | "Freestyler" |
| May 27 | Bomfunk MC's | "Freestyler" |
| June 3 | Milk Inc. | "Walk On Water" |
| June 10 | Milk Inc. | "Walk On Water" |
| June 17 | Bomfunk MC's | "Freestyler" |
| June 24 | Bon Jovi | "It's My Life" |
| July 1 | Bon Jovi | "It's My Life" |
| July 8 | Bon Jovi | "It's My Life" |
| July 15 | Bon Jovi | "It's My Life" |
| July 22 | Live | "They Stood Up for Love" |
| July 29 | Live | "They Stood Up for Love" |
| August 5 | Liquid & Silvy | "Turn the Tide" |
| August 12 | Liquid & Silvy | "Turn the Tide" |
| August 19 | Liquid & Silvy | "Turn the Tide" |
| August 26 | Krezip | "I Would Stay" |
| September 2 | Krezip | "I Would Stay" |
| September 9 | Krezip | "I Would Stay" |
| September 16 | Krezip | "I Would Stay" |
| September 23 | Krezip | "I Would Stay" |
| September 30 | Krezip | "I Would Stay" |
| October 7 | Krezip | "I Would Stay" |
| October 14 | Krezip | "I Would Stay" |
| October 21 | Krezip | "I Would Stay" |
| October 28 | Mozaïek & Walter Grootaers | "Leef" |
| November 4 | Mozaïek & Walter Grootaers | "Leef" |
| November 11 | Mozaïek & Walter Grootaers | "Leef" |
| November 18 | Mozaïek & Walter Grootaers | "Leef" |
| November 25 | Mozaïek & Walter Grootaers | "Leef" |
| December 2 | Mozaïek & Walter Grootaers | "Leef" |
| December 9 | Mozaïek & Walter Grootaers | "Leef" |
| December 16 | Twarres | "Wêr Bisto" |
| December 23 | De Bewoners and Walter Grootaers | "Een Brief Voor Kerstmis" |
| December 30 | De Bewoners and Walter Grootaers | "Een Brief Voor Kerstmis" |