U-157 may refer to one of the following German submarines:
- SM U-157, a German Type U 151 submarine launched in 1917
- German submarine U-157 (1941), a German Type IXC submarine that served in World War II
This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.