Tombusvirus 3′ UTR is an important cis-regulatory region of the Tombus virus genome.[1]
| Tombusvirus 3′ UTR region IV | |
|---|---|
 Predicted secondary structure and sequence conservation of Tombus_3_IV | |
| Identifiers | |
| Symbol | Tombus_3_IV |
| Rfam | RF00176 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Viruses |
| SO | SO:0000205 |
| PDB structures | PDBe |
Tomato bushy stunt virus is the prototype member of the family Tombusviridae. The genome of this virus is positive sense single stranded RNA. Replication occurs via a negative strand RNA intermediate. In addition to viral proteins p33 and the RNA-dependent RNA polymerase p92, and unknown host factors, conserved and structural regions within the 3′ untranslated region (3′ UTR) are important for regulating genome replication. This 3′ structural element contains a pseudoknot.[1][2]
Other non-coding RNA structures in Tombusvirus include the 5′ UTR and an internal replication element.[3]
References edit
- ^ a b Fabian MR, Na H, Ray D, White KA (2003). "3′-Terminal RNA secondary structures are important for accumulation of tomato bushy stunt virus DI RNAs". Virology. 313 (2): 567–580. doi:10.1016/S0042-6822(03)00349-0. PMID 12954222.
- ^ Pogany J, Fabian MR, White KA, Nagy PD (2003). "A replication silencer element in a plus-strand RNA virus". EMBO J. 22 (20): 5602–5611. doi:10.1093/emboj/cdg523. PMC 213777. PMID 14532132.
- ^ Monkewich, S; Lin HX; Fabian MR; Xu W; Na H; Ray D; Chernysheva OA; Nagy PD; White KA (2005). "The p92 Polymerase Coding Region Contains an Internal RNA Element Required at an Early Step in Tombusvirus Genome Replication". J Virol. 79 (8): 4848–4858. doi:10.1128/JVI.79.8.4848-4858.2005. PMC 1069561. PMID 15795270.
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