Tenascin C

Tenascin C
PDB rendering based on 1ten.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1TEN, 2RB8, 2RBL
Identifiers
Symbols	TNC; 150-225; GMEM; GP; HXB; JI; TN; TN-C
External IDs	OMIM: 187380 MGI: 101922 HomoloGene: 55636 GeneCards: TNC Gene
Gene Ontology Molecular function • syndecan binding Cellular component • extracellular region • basement membrane • interstitial matrix • extracellular space • extracellular matrix Biological process • cell adhesion • neuromuscular junction development • positive regulation of cell proliferation • response to wounding • positive regulation of gene expression • peripheral nervous system axon regeneration • mesenchymal-epithelial cell signaling involved in prostate gland development • prostate gland epithelium morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3371	21923
Ensembl	ENSG00000041982	ENSMUSG00000028364
UniProt	P24821	Q80YX1
RefSeq (mRNA)	NM_002160	NM_011607
RefSeq (protein)	NP_002151	NP_035737
Location (UCSC)	Chr 9: 117.78 – 117.88 Mb	Chr 4: 63.96 – 64.05 Mb
PubMed search	[1]	[2]

Tenascin C is a glycoprotein that in humans is encoded by the TNC gene. It is expressed in the extracellular matrix of various tissues during development, disease or injury, and in restricted neurogenic areas of the central nervous system.

In the central nervous system

Expression of Tnc changes from development to adulthood. In the developing central nervous system, Tnc is involved in regulating the proliferation of both oligodendrocyte precursor cells and astrocytes. Expression of Tnc by radial glia precedes the onset of gliogenesis, during which time it is thought to drive the differentiation of astrocytes.

In the adult brain, Tnc expression is downregulated except for the areas that maintain neurogenesis into adulthood and the hypothalamus.

Tnc is also present in central nervous system injuries and gliomas.

Interactions

Tenascin C has been shown to interact with fibronectin.

See also

• Tenascin

Further reading

• Imanaka-Yoshida K, Hiroe M, Yoshida T (2004). "Interaction between cell and extracellular matrix in heart disease: multiple roles of tenascin-C in tissue remodeling.". Histol. Histopathol. 19 (2): 517–25. PMID 15024713. 
• Leahy DJ, Hendrickson WA, Aukhil I, Erickson HP (1992). "Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein.". Science 258 (5084): 987–91. doi:10.1126/science.1279805. PMID 1279805. 
• White DM, Mikol DD, Espinosa R, et al. (1992). "Structure and chromosomal localization of the human gene for a brain form of prostaglandin D2 synthase.". J. Biol. Chem. 267 (32): 23202–8. PMID 1385416. 
• Gulcher JR, Nies DE, Alexakos MJ, et al. (1991). "Structure of the human hexabrachion (tenascin) gene.". Proc. Natl. Acad. Sci. U.S.A. 88 (21): 9438–42. doi:10.1073/pnas.88.21.9438. PMC 52733. PMID 1719530. 
• Gulcher JR, Nies DE, Marton LS, Stefansson K (1989). "An alternatively spliced region of the human hexabrachion contains a repeat of potential N-glycosylation sites.". Proc. Natl. Acad. Sci. U.S.A. 86 (5): 1588–92. doi:10.1073/pnas.86.5.1588. PMC 286743. PMID 2466295. 
• Chung CY, Zardi L, Erickson HP (1996). "Binding of tenascin-C to soluble fibronectin and matrix fibrils.". J. Biol. Chem. 270 (48): 29012–7. doi:10.1074/jbc.270.48.29012. PMID 7499434. 
• Yokosaki Y, Palmer EL, Prieto AL, et al. (1994). "The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin.". J. Biol. Chem. 269 (43): 26691–6. PMID 7523411. 
• Glumoff V, Savontaus M, Vehanen J, Vuorio E (1994). "Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes.". Biochim. Biophys. Acta 1219 (3): 613–22. doi:10.1016/0167-4781(94)90220-8. PMID 7524681. 
• Gherzi R, Carnemolla B, Siri A, et al. (1995). "Human tenascin gene. Structure of the 5'-region, identification, and characterization of the transcription regulatory sequences.". J. Biol. Chem. 270 (7): 3429–34. doi:10.1074/jbc.270.7.3429. PMID 7531707. 
• Weinacker A, Ferrando R, Elliott M, et al. (1995). "Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in human airways.". Am. J. Respir. Cell Mol. Biol. 12 (5): 547–56. PMID 7537970. 
• Schnapp LM, Hatch N, Ramos DM, et al. (1995). "The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin.". J. Biol. Chem. 270 (39): 23196–202. doi:10.1074/jbc.270.39.23196. PMID 7559467. 
• Sriramarao P, Mendler M, Bourdon MA (1993). "Endothelial cell attachment and spreading on human tenascin is mediated by alpha 2 beta 1 and alpha v beta 3 integrins.". J. Cell. Sci. 105 (4): 1001–12. PMID 7693733. 
• Prieto AL, Edelman GM, Crossin KL (1993). "Multiple integrins mediate cell attachment to cytotactin/tenascin.". Proc. Natl. Acad. Sci. U.S.A. 90 (21): 10154–8. doi:10.1073/pnas.90.21.10154. PMC 47732. PMID 7694284. 
• Zagzag D, Friedlander DR, Dosik J, et al. (1996). "Tenascin-C expression by angiogenic vessels in human astrocytomas and by human brain endothelial cells in vitro.". Cancer Res. 56 (1): 182–9. PMID 8548761. 
• Yokosaki Y, Monis H, Chen J, Sheppard D (1996). "Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains.". J. Biol. Chem. 271 (39): 24144–50. doi:10.1074/jbc.271.39.24144. PMID 8798654. 
• Burg MA, Tillet E, Timpl R, Stallcup WB (1996). "Binding of the NG2 proteoglycan to type VI collagen and other extracellular matrix molecules.". J. Biol. Chem. 271 (42): 26110–6. doi:10.1074/jbc.271.42.26110. PMID 8824254. 
• Jones PL, Crack J, Rabinovitch M (1998). "Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alpha v beta 3 integrin to promote epidermal growth factor receptor phosphorylation and growth.". J. Cell Biol. 139 (1): 279–93. doi:10.1083/jcb.139.1.279. PMC 2139818. PMID 9314546. 
• Rauch U, Clement A, Retzler C, et al. (1997). "Mapping of a defined neurocan binding site to distinct domains of tenascin-C.". J. Biol. Chem. 272 (43): 26905–12. doi:10.1074/jbc.272.43.26905. PMID 9341124.