Template:PBB/6532

Solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Identifiers
Symbols	SLC6A4; 5-HTT; 5-HTTLPR; 5HTT; HTT; OCD1; SERT; SERT1; hSERT
External IDs	OMIM: 182138 MGI: 96285 HomoloGene: 817 ChEMBL: 228 GeneCards: SLC6A4 Gene
Gene Ontology Molecular function • serotonin:sodium symporter activity • protein binding • monoamine transmembrane transporter activity • serotonin transmembrane transporter activity • myosin binding • syntaxin-1 binding • Rab GTPase binding • cocaine binding • protein homodimerization activity • nitric-oxide synthase binding • actin filament binding Cellular component • cytosol • plasma membrane • integral to plasma membrane • endosome membrane • endomembrane system • neuron projection • membrane raft Biological process • response to hypoxia • serotonin transport • response to nutrient • memory • circadian rhythm • response to toxic substance • positive regulation of gene expression • monoamine transport • thalamus development • negative regulation of cerebellar granule cell precursor proliferation • negative regulation of synaptic transmission, dopaminergic • response to estradiol stimulus • social behavior • vasoconstriction • response to drug • sperm ejaculation • negative regulation of neuron differentiation • positive regulation of cell cycle • negative regulation of organ growth • brain morphogenesis • protein oligomerization • protein homooligomerization • serotonin uptake • cellular response to retinoic acid • cellular response to cGMP Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6532	15567
Ensembl	ENSG00000108576	ENSMUSG00000020838
UniProt	P31645	Q60857
RefSeq (mRNA)	NM_001045	NM_010484
RefSeq (protein)	NP_001036	NP_034614
Location (UCSC)	Chr 17: 28.52 – 28.56 Mb	Chr 11: 77 – 77.03 Mb
PubMed search	[1]	[2]