Template:PBB/5551

Perforin 1 (pore forming protein)

The structure of a MACPF domain containing protein Plu-MACPF: PDB 2QP2 ^[1] The MACPF domain is in cyan/pink. Another domain, the β prism domain is in orange. Two calcium atoms are in grey.

Identifiers

Symbols

PRF1; FLH2; HPLH2; P1; PFN1; PFP

External IDs

OMIM: 170280 MGI: 97551 HomoloGene: 3698 ChEMBL: 5480 GeneCards: PRF1 Gene

Gene Ontology
Molecular function	• calcium ion binding • protein binding • wide pore channel activity
Cellular component	• extracellular region • plasma membrane • integral to membrane • cytoplasmic membrane-bounded vesicle • endosome lumen • cytolytic granule
Biological process	• defense response to tumor cell • immune response to tumor cell • apoptotic process • cellular defense response • cytolysis • protein homooligomerization • defense response to virus
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
72.36 – 72.36 Mb

Chr 10:
61.3 – 61.3 Mb

PubMed search

[1]

[2]

References

These references will appear in the article, but this list appears only on this page.

^ Rosado CJ, Buckle AM, Law RH, Butcher RE, Kan WT, Bird CH, Ung K, Browne KA, Baran K, Bashtannyk-Puhalovich TA, Faux NG, Wong W, Porter CJ, Pike RN, Ellisdon AM, Pearce MC, Bottomley SP, Emsley J, Smith AI, Rossjohn J, Hartland EL, Voskoboinik I, Trapani JA, Bird PI, Dunstone MA, Whisstock JC (2007). "A common fold mediates vertebrate defense and bacterial attack". Science 317 (5844): 1548–51. doi:10.1126/science.1144706. PMID 17717151.

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Last modified on 9 May 2013, at 09:05