Template:PBB/4215

Mitogen-activated protein kinase kinase kinase 3
PDB rendering based on 2c60.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2C60, 2JRH, 2O2V, 2PPH
Identifiers
Symbols	MAP3K3; MAPKKK3; MEKK3
External IDs	OMIM: 602539 MGI: 1346874 HomoloGene: 69110 ChEMBL: 5970 GeneCards: MAP3K3 Gene
EC number	2.7.11.25
Gene Ontology Molecular function • protein kinase activity • MAP kinase kinase kinase activity • protein binding • ATP binding • metal ion binding Cellular component • cytosol Biological process • MAPK cascade • activation of MAPKK activity • intracellular protein kinase cascade • positive regulation of I-kappaB kinase/NF-kappaB cascade • protein autophosphorylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4215	26406
Ensembl	ENSG00000198909	ENSMUSG00000020700
UniProt	Q99759	Q61084
RefSeq (mRNA)	NM_002401	NM_011947
RefSeq (protein)	NP_002392	NP_036077
Location (UCSC)	Chr 17: 61.7 – 61.77 Mb	Chr 11: 106.08 – 106.16 Mb
PubMed search	[1]	[2]