Talk:Hepatitis B virus

Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 18 August 2020 and 4 December 2020. Further details are available on the course page. Student editor(s): Pepperonys. Peer reviewers: OMIHEP.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 23:21, 16 January 2022 (UTC)

positive case of hbv in immunised individual

positive case of hbv in immunised individual. need to knw abt any immunisation after the occurence of the infection. —Preceding unsigned comment added by 59.97.233.101 (talk) 10:29, 11 August 2009 (UTC)

Please note admonition above, "This is the talk page for discussing improvements to the Hepatitis B virus article." Also explained at the Talk page guidelines. Do you have a suggestion for improving this article? --Scray (talk) 01:50, 12 August 2009 (UTC)

Bad/Wrong Picture

The 'simplified' picture in the morphology section is pretty bad and should probably be changed or removed, as it might confuse people seeking to visualize the HBV particle. In the picture, HBcAg or 'Core' antigen is labeled as a series of red circles surrounding a blue icosahedron containing DNA. In actuality, the HBcAg protein actually is what the icosahedral capsid is built from. The picture kind of implies that the icosahedral capsid is constructed of some un-named molecules, then surrounded by a sphere of HBcAg proteins; which is not correct. 72.94.61.107 (talk) 06:42, 19 February 2011 (UTC)

There's another issue with the picture, I believe. The full DNA strand should be the negative-sense (-) one, as is shown in the genome picture of the article, and not the positive-sense (+) one. The negative-sense one is the one with the DNApol at one ending, as well. (Pepemonbu (talk) 19:53, 2 May 2011 (UTC))

I agree. I have removed the diagram. It seems to have been altered since I drew the original cartoon. I will try to replace it with a more accurate version. Graham Colm (talk) 21:31, 2 May 2011 (UTC)

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Added to Disease section

Hi, I thought it would be helpful to include that is there is a vaccine to prevent Hepatitis B: "Despite there being a vaccine to prevent Hepatitis B, HBV remains a global health problem. Hepatitis B can be acute and later become chronic, leading to other diseases and health conditions[4]." Would this be beneficial for the article?Pepperonys (talk) 03:38, 20 September 2020 (UTC)

Picture of 'The Genome organization of HBV. The genes overlap'

I believe that the polarity of the minus strand and the plus strand are reversed in the picture. The minus strand should be 5' to 3' in counterclockwise direction. The plus strand should be 5' to 3' in the clock wise direction. Stfraw (talk) 07:36, 2 December 2020 (UTC)

Surely that doesn't matter? It could be drawn as a mirror image (ie. from the other side). Or am I missing something? Graham Beards (talk) 12:16, 2 December 2020 (UTC)

Since the open reading frames for the viral protein are shown directional (arrows), the picture now implies that the -strand represents the coding strand. But it should be the +strand. Wouldn't you agree? Stfraw (talk) 13:01, 2 December 2020 (UTC)

Please take a look at this diagram: [1]. Graham Beards (talk) 15:02, 2 December 2020 (UTC)

I very much agree with that diagram. It actually supports my point. The plus-strand is only partially completed and is the one that codes for the viral proteins. Stfraw (talk) 15:30, 2 December 2020 (UTC) See also Figure 2 (and legend) in this review [2] Stfraw (talk) 15:40, 2 December 2020 (UTC)

It's a DNA virus.The negative sense strand is used as the template for mRNA. Graham Beards (talk) 16:14, 2 December 2020 (UTC)

See [3]. Graham Beards (talk) 16:20, 2 December 2020 (UTC)

I am sorry, but the Figure in that review is wrong too. It would be correctly labeled if it meant the pgRNA (both in the review you cite and in the figure on the wikipedia page) and that would fit with the direction and position of the viral protein coding regions. The minus strand DNA is produced from the pgRNA by reverse transcription and thus has opposite polarity. Second strand DNA synthesis will produce the positive strand DNA that again has the same polarity as the pgRNA and the encoded proteins. Stfraw (talk) 16:35, 2 December 2020 (UTC)

I have tweaked the diagram. You might need to flush your cache. Graham Beards (talk) 18:59, 2 December 2020 (UTC)

Looks great :-) 84.75.106.18 (talk) 19:19, 2 December 2020 (UTC)

Wiki Education assignment: Virology 2022

This article was the subject of a Wiki Education Foundation-supported course assignment, between 23 August 2022 and 15 December 2022. Further details are available on the course page. Student editor(s): Blynnski34 (article contribs).

— Assignment last updated by Blynnski34 (talk) 00:14, 18 November 2022 (UTC)