Talk:Epinephrine

Last edit "epinephrine is synthetic adrenaline"

I have no ability to say whether this is correct, but it seems inconsistent with the Terminology and other sections? 122.106.177.130 (talk) 07:27, 18 February 2012 (UTC)

Yes, that edit was misleading, so I have reverted it. -- Ed (Edgar181) 12:07, 18 February 2012 (UTC)

Cardiac arrest

I've just reverted an edit about a recent large observational study of the immediate and one-month outcomes from the use of epinephrine in cardiac arrest patients prior to hospital arrival. The abstract is here. Though it's a large (>400,000 subjects) study it's afflicted by many limitations common to observational studies, and, as a primary source, is not recommended for health-related content, per WP:MEDRS. Once the findings have been replicated, or supported by better controlled evidence, and it's all contextualised in a systematic review or similar, we'll have a better understanding of its value. --Anthonyhcole (talk) 04:37, 23 March 2012 (UTC)

I'd say that it's more than a little hasty to remove that without discussing it here. Although you do have a point, the source is not so questionable to warrant it's immediate removable. I'd actually advise keeping it in the article, but writing it in in such a way that it is not stated as a hard fact, but a possibility (i.e "a study published in the Journal of American Medical Association suggests a correlation between a temporary spontaneous recovery and epinephrin administration in cardiac arrest patients."). There's also the fact that the mechanism of which epinephrin can assist cardiac arrest patients is well known and described earlier in this very article. In the "Medical Uses" section, there is a well-sourced paragraph detailing epinephrin's use in emergency treatment of cardiac arrest, and hence this study is not the first suggesting a connection. In fact, epinephrin is commonly used by hospitals along with defibrillators to correct arrhythmia (defibrillators are useless for complete heart cessation, but epinephrin may help). Due to all of this, it's not appropriate to make the decision yourself, as primary sources are acceptable, as long as they are not misused (used to claim something is a verified fact, vs a possibility). LiamSP (talk) 16:46, 23 March 2012 (UTC)

Terminology section

Resolved

I'm finding it hard to verify the unsourced assertion that the word epinephrine was chosen due to a clash with a trademark. this source says that epinepherine was chosen by the first isolators of the chemical, Abel and Crawford in 1897. That paper has some interesting things to say about the etymology of the words, and might be a good source for the terminology section. 137.43.188.74 (talk) 19:50, 19 April 2012 (UTC)

Seems weird too since Adrenalin is just a trademark for epinephrine, so how did a brand name come before the chemical name? C6541 (T↔C) 19:59, 19 April 2012 (UTC)

It actually seems that there was a grain of truth in the trademark issue, I have updated the article with more information about this from a BMJ article I found. 137.43.188.169 (talk) 18:29, 23 April 2012 (UTC)

Is epinephrine neurotoxic to the nerves in some dental procedures?

About dental procedures as a cause of trigeminal neuralgias,in the book "Striking back: The trigeminal neuralgia and face pain handbook" it is written: "Dr Gremillion says that the local anesthetics that dentists use to numb an area before fixing a cavity can even act as a trigger. He says these are mild "neurotoxins" - agents that irritate nerves. Most of the short-acting anesthetics also contain epinephrine,he adds. Epinephrine is a vessel-constricting chemical that's used to prolong the numbing effect,but it also can trigger nerve pain."

I'm an atypical trigeminal neuralgia patient which began after a wisdom tooth extraction,the upper left wisdom tooth,in that procedure it was used epinephrine. Before that extraction,I had only rarely light pain near the tooth which was extracted one year later,the upper left wisdom tooth,and it was that extraction,that caused atypical trigeminal neuralgia. I have bad occlusion too and I had sometimes atypical odontalgia (I felt like it was a cavity but the cavity wasn't there) in the teeth near the upper left wisdom tooth. (79.17.249.117 (talk) 21:20, 15 October 2012 (UTC))

Vasodilator or Vasoconstrictor ?

This article is confusing as to whether Epinephrine is a Vasodilator or a Vasoconstrictor. From other sources I gather that is can be either. In low doses it is a Vasodilator, and at high doses it is a Vasoconstrictor.

This page says its a Vasoconstrictor http://en.wikipedia.org/wiki/Vasoconstriction

and these pages say it is a Vasodilator http://en.wikipedia.org/wiki/Vasodilation http://en.wikipedia.org/wiki/Endocrine_system

EricStruble (talk) 04:05, 2 March 2013 (UTC)