Thioredoxin domain-containing protein 5 is a protein that in humans is encoded by the TXNDC5 gene.[5]

TXNDC5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTXNDC5, ENDOPDI, ERP46, HCC-2, PDIA15, STRF8, UNQ364, HCC2, thioredoxin domain containing 5
External IDsOMIM: 616412 MGI: 2145316 HomoloGene: 11125 GeneCards: TXNDC5
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_030810
NM_001145549
NM_022085

NM_001289598
NM_001289599
NM_145367

RefSeq (protein)

NP_001139021
NP_110437

NP_001276527
NP_001276528
NP_663342

Location (UCSC)Chr 6: 7.88 – 7.91 MbChr 13: 38.68 – 38.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

This gene encodes a protein disulfide-isomerase.[6] Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. This gene can be co-transcribed with the upstream gene MUTED.[5]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000239264 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038991 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: TXNDC5 thioredoxin domain containing 5".
  6. ^ Galligan JJ, Petersen DR (July 2012). "The human protein disulfide isomerase gene family". Human Genomics. 6 (6): 6. doi:10.1186/1479-7364-6-6. PMC 3500226. PMID 23245351.

Further reading edit