TRD (gene)

T cell receptor delta locus (symbol TRD), also known as TCRD or TRD@, is a protein that in humans is encoded by the TRD gene. It contributes the delta (δ) chain to the larger TCR protein (T-cell receptor).

TRD
Identifiers
Aliases	TRD, TCRD, TCRDV1, TRD@, T cell receptor delta locus, T-cell receptor delta locus
External IDs	GeneCards: TRD
Orthologs Species Human Mouse Entrez 6964 n/a Ensembl n/a n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a
Wikidata
View/Edit Human

Further reading

• Chien YH, Iwashima M, Kaplan KB, Elliott JF, Davis MM (1987). "A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation". Nature. 327 (6124): 677–82. Bibcode:1987Natur.327..677C. doi:10.1038/327677a0. PMID 2439914. S2CID 4327838.
• Hayes SM, Shores EW, Love PE (February 2003). "An architectural perspective on signaling by the pre-, alphabeta and gammadelta T cell receptors". Immunological Reviews. 191: 28–37. doi:10.1034/j.1600-065X.2003.00011.x. PMID 12614349. S2CID 28556794.
• Guglielmi P, Davi F, d'Auriol L, Bories JC, Dausset J, Bensussan A (August 1988). "Use of a variable alpha region to create a functional T-cell receptor delta chain". Proceedings of the National Academy of Sciences of the United States of America. 85 (15): 5634–8. Bibcode:1988PNAS...85.5634G. doi:10.1073/pnas.85.15.5634. PMC 281814. PMID 2456576.
• Hochstenbach F, Brenner MB (August 1989). "T-cell receptor delta-chain can substitute for alpha to form a beta delta heterodimer". Nature. 340 (6234): 562–5. Bibcode:1989Natur.340..562H. doi:10.1038/340562a0. PMID 2528071. S2CID 29948685.
• Dyer MJ (August 1989). "T-cell receptor delta/alpha rearrangements in lymphoid neoplasms". Blood. 74 (3): 1073–83. doi:10.1182/blood.V74.3.1073.1073. PMID 2546634.
• Griesinger F, Greenberg JM, Kersey JH (August 1989). "T cell receptor gamma and delta rearrangements in hematologic malignancies. Relationship to lymphoid differentiation". The Journal of Clinical Investigation. 84 (2): 506–16. doi:10.1172/JCI114193. PMC 548910. PMID 2547833.
• Loh EY, Lanier LL, Turck CW, Littman DR, Davis MM, Chien YH, Weiss A (1988). "Identification and sequence of a fourth human T cell antigen receptor chain". Nature. 330 (6148): 569–72. doi:10.1038/330569a0. PMID 2825032. S2CID 4362226.
• Bartkowiak J, Kulczyck-Wojdala D, Blonski JZ, Robak T (2002). "Molecular diversity of gammadelta T cells in peripheral blood from patients with B-cell chronic lymphocytic leukaemia". Neoplasma. 49 (2): 86–90. PMID 12088111.
• Oyoshi MK, Nagata H, Kimura N, Zhang Y, Demachi A, Hara T, Kanegane H, Matsuo Y, Yamaguchi T, Morio T, Hirano A, Shimizu N, Yamamoto K (May 2003). "Preferential expansion of Vgamma9-JgammaP/Vdelta2-Jdelta3 gammadelta T cells in nasal T-cell lymphoma and chronic active Epstein-Barr virus infection". The American Journal of Pathology. 162 (5): 1629–38. doi:10.1016/S0002-9440(10)64297-6. PMC 1851204. PMID 12707047.
• Krejci O, Prouzova Z, Horvath O, Trka J, Hrusak O (July 2003). "Cutting edge: TCR delta gene is frequently rearranged in adult B lymphocytes". Journal of Immunology. 171 (2): 524–7. doi:10.4049/jimmunol.171.2.524. PMID 12847212.
• van Hagen PM, Hooijkaas H, Vd Beemd MW, Verjans G, Baarsma GS (2003). T-γδ Receptor Restriction in Peripheral Lymphocytes of Patients with Behçet's Disease. Advances in Experimental Medicine and Biology. Vol. 528. pp. 267–8. doi:10.1007/0-306-48382-3_53. ISBN 0-306-47757-2. PMID 12918704.
• Szczepanski T, van der Velden VH, Hoogeveen PG, de Bie M, Jacobs DC, van Wering ER, van Dongen JJ (May 2004). "Vdelta2-Jalpha rearrangements are frequent in precursor-B-acute lymphoblastic leukemia but rare in normal lymphoid cells". Blood. 103 (10): 3798–804. doi:10.1182/blood-2003-08-2952. PMID 14656882.
• De Rosa SC, Andrus JP, Perfetto SP, Mantovani JJ, Herzenberg LA, Herzenberg LA, Roederer M (February 2004). "Ontogeny of gamma delta T cells in humans". Journal of Immunology. 172 (3): 1637–45. doi:10.4049/jimmunol.172.3.1637. PMID 14734745. S2CID 9207247.
• Fronková E, Krejcí O, Kalina T, Horváth O, Trka J, Hrusák O (August 2005). "Lymphoid differentiation pathways can be traced by TCR delta rearrangements". Journal of Immunology. 175 (4): 2495–500. doi:10.4049/jimmunol.175.4.2495. PMID 16081821.
• Chauhan SK, Tripathy NK, Sinha N, Nityanand S (2006). "T-cell receptor repertoire of circulating gamma delta T-cells in Takayasu's arteritis". Clinical Immunology. 118 (2–3): 243–9. doi:10.1016/j.clim.2005.10.010. PMID 16307908.
• Joachims ML, Chain JL, Hooker SW, Knott-Craig CJ, Thompson LF (February 2006). "Human alpha beta and gamma delta thymocyte development: TCR gene rearrangements, intracellular TCR beta expression, and gamma delta developmental potential--differences between men and mice". Journal of Immunology. 176 (3): 1543–52. doi:10.4049/jimmunol.176.3.1543. PMC 1592528. PMID 16424183.
• Karrman K, Andersson A, Björgvinsdóttir H, Strömbeck B, Lassen C, Olofsson T, Nguyen-Khac F, Berger R, Bernard O, Fioretos T, Johansson B (July 2006). "Deregulation of cyclin D2 by juxtaposition with T-cell receptor alpha/delta locus in t(12;14)(p13;q11)-positive childhood T-cell acute lymphoblastic leukemia". European Journal of Haematology. 77 (1): 27–34. doi:10.1111/j.0902-4441.2006.t01-1-EJH2553.x. PMID 16548914. S2CID 22205994.
• Touvrey C, Borel E, Marche PN, Jouvin-Marche E, Candéias SM (2006). "Gene-specific signal joint modifications during V(D)J recombination of TCRAD locus genes in murine and human thymocytes". Immunobiology. 211 (9): 741–51. doi:10.1016/j.imbio.2006.04.001. PMID 17015149.