TNNI2

Troponin I type 2 (skeletal, fast)
PDB rendering based on 1a2x.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1a2x, 1vdi, 1vdj
Identifiers
Symbols	TNNI2; AMCD2B; DA2B; FSSV; fsTnI
External IDs	OMIM: 191043 MGI: 105070 HomoloGene: 37752 GeneCards: TNNI2 Gene
Gene Ontology Molecular function • actin binding • protein binding • troponin T binding Cellular component • nucleus • cytosol • troponin complex Biological process • skeletal muscle contraction • muscle filament sliding • positive regulation of transcription, DNA-dependent Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7136	21953
Ensembl	ENSG00000130598	ENSMUSG00000031097
UniProt	P48788	P13412
RefSeq (mRNA)	NM_001145829	NM_009405
RefSeq (protein)	NP_001139301	NP_033431
Location (UCSC)	Chr 11: 1.86 – 1.86 Mb	Chr 7: 142.44 – 142.44 Mb
PubMed search	[1]	[2]

Troponin I, fast skeletal muscle is a protein that in humans is encoded by the TNNI2 gene.

Further reading

• Kinoshita S, Adachi W, Sotozono C, et al. (2001). "Characteristics of the human ocular surface epithelium.". Progress in retinal and eye research 20 (5): 639–73. doi:10.1016/S1350-9462(01)00007-6. PMID 11470454. 
• Wade R, Eddy R, Shows TB, Kedes L (1990). "cDNA sequence, tissue-specific expression, and chromosomal mapping of the human slow-twitch skeletal muscle isoform of troponin I.". Genomics 7 (3): 346–57. doi:10.1016/0888-7543(90)90168-T. PMID 2365354. 
• Huang TS, Bylund DB, Stull JT, Krebs EG (1974). "The amino acid sequences of the phosphorylated sites in troponin-I from rabbit skeletal muscle.". FEBS Lett. 42 (3): 249–52. doi:10.1016/0014-5793(74)80738-6. PMID 4369265. 
• Moir AJ, Ordidge M, Grand RJ, et al. (1983). "Studies of the interaction of troponin I with proteins of the I-filament and calmodulin.". Biochem. J. 209 (2): 417–26. PMC 1154108. PMID 6847627. 
• Grand RJ, Levine BA, Perry SV (1982). "Proton-magnetic-resonance studies on the interaction of rabbit skeletal-muscle troponin I with troponin C and actin.". Biochem. J. 203 (1): 61–8. PMC 1158193. PMID 7103951. 
• Chong PC, Hodges RS (1982). "Photochemical cross-linking between rabbit skeletal troponin subunits. Troponin I-troponin T interactions.". J. Biol. Chem. 257 (19): 11667–72. PMID 7118902. 
• Zhu L, Perez-Alvarado G, Wade R (1994). "Sequencing of a cDNA encoding the human fast-twitch skeletal muscle isoform of troponin I.". Biochim. Biophys. Acta 1217 (3): 338–40. PMID 8148383. 
• Lanfranchi G, Muraro T, Caldara F, et al. (1996). "Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization.". Genome Res. 6 (1): 35–42. doi:10.1101/gr.6.1.35. PMID 8681137. 
• Jha PK, Leavis PC, Sarkar S (1997). "Interaction of deletion mutants of troponins I and T: COOH-terminal truncation of troponin T abolishes troponin I binding and reduces Ca2+ sensitivity of the reconstituted regulatory system.". Biochemistry 35 (51): 16573–80. doi:10.1021/bi9622433. PMID 8987992. 
• Stefancsik R, Jha PK, Sarkar S (1998). "Identification and mutagenesis of a highly conserved domain in troponin T responsible for troponin I binding: potential role for coiled coil interaction.". Proc. Natl. Acad. Sci. U.S.A. 95 (3): 957–62. doi:10.1073/pnas.95.3.957. PMC 18637. PMID 9448267. 
• Vassylyev DG, Takeda S, Wakatsuki S, et al. (1998). "Crystal structure of troponin C in complex with troponin I fragment at 2.3-A resolution.". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 4847–52. doi:10.1073/pnas.95.9.4847. PMC 20176. PMID 9560191. 
• Jha PK, Sarkar S (1998). "A recombinant monocysteine mutant (Ser to Cys-155) of fast skeletal troponin T: identification by cross-linking of a domain involved in a physiologically relevant interaction with troponins C and I.". Biochemistry 37 (35): 12253–60. doi:10.1021/bi980025z. PMID 9724539. 
• Moses MA, Wiederschain D, Wu I, et al. (1999). "Troponin I is present in human cartilage and inhibits angiogenesis.". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2645–50. doi:10.1073/pnas.96.6.2645. PMC 15822. PMID 10077564. 
• Mullen AJ, Barton PJ (2000). "Structural characterization of the human fast skeletal muscle troponin I gene (TNNI2).". Gene 242 (1–2): 313–20. doi:10.1016/S0378-1119(99)00519-3. PMID 10721725. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Sung SS, Brassington AM, Grannatt K, et al. (2003). "Mutations in genes encoding fast-twitch contractile proteins cause distal arthrogryposis syndromes". Am. J. Hum. Genet. 72 (3): 681–90. doi:10.1086/368294. PMC 1180243. PMID 12592607. 
• Li Q, Liu Y, Shen PY, et al. (2003). "Troponin I binds polycystin-L and inhibits its calcium-induced channel activation". Biochemistry 42 (24): 7618–25. doi:10.1021/bi034210a. PMID 12809519. 
• Thijssen VL, Ausma J, Gorza L, et al. (2005). "Troponin I isoform expression in human and experimental atrial fibrillation". Circulation 110 (7): 770–5. doi:10.1161/01.CIR.0000138849.03311.C6. PMID 15289369.