TANK (gene)

TRAF family member-associated NF-kappa-B activator is a protein that in humans is encoded by the TANK gene.

TANK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KZZ, 1L0A
Identifiers
Aliases	TANK, I-TRAF, ITRAF, TRAF2, TRAF family member associated NFKB activator
External IDs	OMIM: 603893 MGI: 107676 HomoloGene: 3081 GeneCards: TANK
Gene location (Human) Chr. Chromosome 2 (human) Band 2q24.2 Start 161,136,908 bp End 161,236,230 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 C1.3 Start 61,578,585 bp End 61,654,171 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte Achilles tendon germinal epithelium bone marrow cells lactiferous duct gallbladder spongy bone lymph node lower lobe of lung right lung Top expressed in submandibular gland Paneth cell spleen subcutaneous adipose tissue white adipose tissue secondary oocyte thymus dermis epidermis hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin protein ligase binding metal ion binding deubiquitinase activator activity thiol-dependent deubiquitinase Cellular component cytoplasm cytosol protein-containing complex Biological process TRIF-dependent toll-like receptor signaling pathway signal transduction positive regulation of ubiquitin-specific protease activity positive regulation of protein deubiquitination cellular response to tumor necrosis factor negative regulation of I-kappaB kinase/NF-kappaB signaling cellular response to interleukin-1 proteolysis cellular response to ionizing radiation cellular response to DNA damage stimulus I-kappaB kinase/NF-kappaB signaling viral process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10010 21353 Ensembl ENSG00000136560 ENSMUSG00000064289 UniProt Q92844 Q6NW12 P70347 RefSeq (mRNA) NM_001199135 NM_004180 NM_133484 NM_001164071 NM_001164072 NM_011529 NM_001355267 NM_001355268 NM_001374667 NM_001378922 RefSeq (protein) NP_001186064 NP_004171 NP_597841 NP_001186064.1 NP_001157543 NP_001157544 NP_035659 NP_001342196 NP_001342197 NP_001361596 NP_001365851 Location (UCSC) Chr 2: 161.14 – 161.24 Mb Chr 2: 61.58 – 61.65 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Two transcript variants encoding different isoforms have been found for this gene.

Interactions

TANK (gene) has been shown to interact with TANK-binding kinase 1, IKBKE, TRAF2, IKBKG and TRAF3.

Further reading

• Chin AI, Shu J, Shan Shi C, Yao Z, Kehrl JH, Cheng G (October 1999). "TANK potentiates tumor necrosis factor receptor-associated factor-mediated c-Jun N-terminal kinase/stress-activated protein kinase activation through the germinal center kinase pathway". Molecular and Cellular Biology. 19 (10): 6665–72. doi:10.1128/MCB.19.10.6665. PMC 84649. PMID 10490605.
• Pomerantz JL, Baltimore D (December 1999). "NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase". The EMBO Journal. 18 (23): 6694–704. doi:10.1093/emboj/18.23.6694. PMC 1171732. PMID 10581243.
• Nomura F, Kawai T, Nakanishi K, Akira S (March 2000). "NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation". Genes to Cells. 5 (3): 191–202. doi:10.1046/j.1365-2443.2000.00315.x. PMID 10759890. S2CID 8489218.
• Zapata JM, Pawlowski K, Haas E, Ware CF, Godzik A, Reed JC (June 2001). "A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains". The Journal of Biological Chemistry. 276 (26): 24242–52. doi:10.1074/jbc.M100354200. PMID 11279055.
• Li C, Ni CZ, Havert ML, Cabezas E, He J, Kaiser D, Reed JC, Satterthwait AC, Cheng G, Ely KR (March 2002). "Downstream regulator TANK binds to the CD40 recognition site on TRAF3". Structure. 10 (3): 403–11. doi:10.1016/S0969-2126(02)00733-5. PMID 12005438.
• Chariot A, Leonardi A, Muller J, Bonif M, Brown K, Siebenlist U (October 2002). "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases". The Journal of Biological Chemistry. 277 (40): 37029–36. doi:10.1074/jbc.M205069200. PMID 12133833.
• Ishida R, Ezura Y, Emi M, Kajita M, Yoshida H, Suzuki T, Hosoi T, Inoue S, Shiraki M, Ito H, Orimo H (August 2003). "Association of a promoter haplotype (-1542G/-525C) in the tumor necrosis factor receptor associated factor-interacting protein gene with low bone mineral density in Japanese women". Bone. 33 (2): 237–41. doi:10.1016/S8756-3282(03)00226-6. PMID 14499357.
• Li C, Norris PS, Ni CZ, Havert ML, Chiong EM, Tran BR, Cabezas E, Reed JC, Satterthwait AC, Ware CF, Ely KR (December 2003). "Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling". The Journal of Biological Chemistry. 278 (50): 50523–9. doi:10.1074/jbc.M309381200. PMID 14517219.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Bonif M, Meuwis MA, Close P, Benoit V, Heyninck K, Chapelle JP, Bours V, Merville MP, Piette J, Beyaert R, Chariot A (March 2006). "TNFalpha- and IKKbeta-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKgamma and NF-kappaB activation". The Biochemical Journal. 394 (Pt 3): 593–603. doi:10.1042/BJ20051659. PMC 1383709. PMID 16336209.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Guo B, Cheng G (April 2007). "Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK". The Journal of Biological Chemistry. 282 (16): 11817–26. doi:10.1074/jbc.M700017200. PMID 17327220.
• Ryzhakov G, Randow F (July 2007). "SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK". The EMBO Journal. 26 (13): 3180–90. doi:10.1038/sj.emboj.7601743. PMC 1914091. PMID 17568778.
• Gatot JS, Gioia R, Chau TL, Patrascu F, Warnier M, Close P, Chapelle JP, Muraille E, Brown K, Siebenlist U, Piette J, Dejardin E, Chariot A (October 2007). "Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF". The Journal of Biological Chemistry. 282 (43): 31131–46. doi:10.1074/jbc.M701690200. PMID 17823124.

External links

• TANK human gene location in the UCSC Genome Browser.
• TANK human gene details in the UCSC Genome Browser.